- The DPE, a core promoter element for transcription by RNA polymerase II
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Kadonaga J
- KMID: 931875
- Exp Mol Med.
- 2002 Sep;34(4):259-264.
The core promoter is an important yet often overlooked component in the regulation of transcription by RNA polymerase II. In fact, the core promoter is the ultimate target of... -
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- Characterization of cis-acting elements in the rat ATP citrate-lyase gene promoter
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Moon YA, Park SW, Kim KS
- KMID: 1093599
- Exp Mol Med.
- 2002 Mar;34(1):60-68.
The cis-acting element in the promoter of the rat ATP-citrate lyase (ACL) and transcription factors which interact with these elements were determined. Six Sp1 binding sites and CAAT box exist... -
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- Development of an efficient endothelial cell specific vector using promoter and 5' untranslated sequences from the human preproendothelin-1 gene
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Cho JY, Lim WC, Jang S, Lee YJ
- KMID: 1109315
- Exp Mol Med.
- 2003 Aug;35(4):269-274.
We report here, that a vector constructed based on ppET-1 gene promoter and 5' untranslated region induced a high level of gene expression in endothelial cells and the specificity is... -
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- Interleukin-10 Promoter Polymorphism is Associated with the Predisposition to the Development of IgA Nephropathy and Focal Segmental Glomerulosclerosis in Korea
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Chin HJ, Na KY, Kim SJ, Oh KH, Kim YS, Lim CS, Kim S, Chae DW
- KMID: 2157750
- J Korean Med Sci.
- 2005 Dec;20(6):989-993.
- doi: 10.3346/jkms.2005.20.6.989
The roles of interleukin-10 (IL-10) have been emphasized in several models of glomerulonephritis (GN). Three biallelic polymorphisms within the IL-10 promoter region, at positions -1,082, -819, and -592 from the... -
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- Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter
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Im SS, Kim JW, Kim TH, Song XL, Kim SY, Kim HI, Ahn YH
- KMID: 755748
- Exp Mol Med.
- 2005 Apr;37(2):101-110.
In the present study, we show that the expression of type 2 glucose transporter isoform (GLUT2) could be regulated by PPAR-gamma in the liver. Rosiglitazone, PPAR-gamma agonist, activated the GLUT2... -
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- Improved expression by cytomegalovirus promoter/enhancer and behavior of vascular endothelial growth factor gene after myocardial injection of naked DNA
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Jeong JO, Byun JH, Jeon ES, Gwon HC, Lim YS, Park JW, Yeo SJ, Lee YJ, Kim SY, Kim DK
- KMID: 931878
- Exp Mol Med.
- 2002 Sep;34(4):278-284.
Direct injection of the vascular endothelial growth factor (VEGF) gene plasmid DNA into the myocardium was shown to induce development of new blood vessels to increase the circulation in... -
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- Evaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients
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Seo JC, Han SW, Yin CS, Koh HK, Kim CH, Kim EH, Leem KH, Lee HS, Park HJ, Kim SA, Choe BK, Lee HJ, Yim SV, Kim CJ, Chung JH
- KMID: 931880
- Exp Mol Med.
- 2002 Sep;34(4):294-298.
Apoptosis has been implicated in the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. Apo-1/Fas gene is one of the mediators of apoptosis in stroke. MvaI polymorphism... -
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- Cell-type specific regulation of thrombospondin-1 expression and its promoter activity by regulatory agents
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Kim SA, Kang JH, Cho IH, Bae SW, Hong KJ
- KMID: 938874
- Exp Mol Med.
- 2001 Sep;33(3):117-123.
Thrombospondin-1 (TSP-1), a multifunctional protein that is able to function as a negative regulator of solid tumor progression and angiogenesis, is normally present at a very low level but rapidly... -
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- A Single Nucleotide Polymorphism in the E-cadherin Gene Promoter-160 is Not Associated with Risk of Korean Gastric Cancer
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Park WS, Cho YG, Park JY, Kim CJ, Lee JH, Kim HS, Lee JW, Song YH, Park CH, Park YK, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY
- KMID: 648900
- J Korean Med Sci.
- 2003 Aug;18(4):501-504.
- doi: 10.3346/jkms.2003.18.4.501
Recently, the -160 C/A polymorphism, located within the regulatory region of E-cadherin promoter, has been shown to influence E-cadherin transcription by altering transcription factor binding. We examined the effect of... -
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