Korean J Intern Med.
2021 Nov;36(6):1437-1449. 10.3904/kjim.2021.326.
Nicotine exacerbates tacrolimus-induced renal injury by programmed cell death
- Jiang YJ1
- Cui S1,2
- Luo K1,3
- Ding J1
- Nan QY1,4
- Piao SG1
- Xuan MY1,5
- Zheng HL1
- Jin YJ1,2
- Jin JZ1
- Lee JP6
- Chung BH2,7
- Choi BS2,7
- Yang CW2,7
- Li C
1
- Affiliations
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- 1Department of Nephrology, Yanbian University Hospital, Yanji, China
- 2Transplantation Research Center, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
- 3Postdoctoral Research Institute for Basic Medicine, Yanbian University College of Medicine, Yanji, China
- 4Department of Intensive Care Unit, Yanbian University Hospital, Yanji, China
- 5Department of Health Examination Central, Yanbian University, Yanji, China
- 6Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea
- 7Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
- KMID: 2521739
- DOI: http://doi.org/10.3904/kjim.2021.326
Abstract
- Background/Aims
Cigarette smoking is an important modifiable risk factor in kidney disease progression. However, the underlying mechanisms for this are lacking. This study aimed to assess whether nicotine (NIC), a major toxic component of cigarette smoking, would exacerbates tacrolimus (TAC)-induced renal injury.
Methods
Sprague-Dawley rats were treated daily with NIC, TAC, or both drugs for 4 weeks. The influence of NIC on TAC-caused renal injury was examined via renal function, histopathology, oxidative stress, mitochondria, endoplasmic reticulum (ER) stress, and programmed cell death (apoptosis and autophagy).
Results
Both NIC and TAC significantly impaired renal function and histopathology, while combined NIC and TAC treatment aggravated these parameters beyond the effects of either alone. Increased oxidative stress, ER stress, mitochondrial dysfunction, proinf lammatory and profibrotic cytokine expressions, and programmed cell death from either NIC or TAC were also aggravated by the two combined.
Conclusions
Our observations suggest that NIC exacerbates chronic TAC nephrotoxicity, implying that smoking cessation may be beneficial for transplant smokers taking TAC.
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