- Nicotine exacerbates tacrolimus-induced renal injury by programmed cell death
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Jiang YJ, Cui S, Luo K, Ding J, Nan QY, Piao SG, Xuan MY, Zheng HL, Jin YJ, Jin JZ, Lee JP, Chung BH, Choi BS, Yang CW, Li C
- KMID: 2521739
- Korean J Intern Med.
- 2021 Nov;36(6):1437-1449.
- doi: 10.3904/kjim.2021.326
Background/Aims: Cigarette smoking is an important modifiable risk factor in kidney disease progression. However, the underlying mechanisms for this are lacking. This study aimed to assess whether nicotine (NIC), a... -
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- Assessment of nephrotoxicity of herbal medicine containing aristolochic acid in mice
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Quan Y, Jin L, Luo K, Jin J, Lim SW, Shin YJ, Ko EJ, Chung BH, Yang CW
- KMID: 2502026
- Korean J Intern Med.
- 2020 Mar;35(2):400-407.
- doi: 10.3904/kjim.2018.280
Background/Aims: It is undetermined if herbal medicines (HM) containing aristolochic acid (AA)-containing have similar nephrotoxicity to AA itself. Methods: We administered HM containing a high concentration of AA for 5 days... -
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- Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells
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Lim SW, Kim KW, Kim BM, Shin YJ, Luo K, Quan Y, Cui S, Ko EJ, Chung BH, Yang CW
- KMID: 2527304
- Korean J Intern Med.
- 2022 Mar;37(2):411-424.
- doi: 10.3904/kjim.2020.438
Background/Aims: Renal ischemia followed by reperfusion (I/R) is a leading cause of acute kidney injury (AKI), which is closely associated with high morbidity and mortality. Studies have shown that induced... -
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- The therapeutic efficacy of water-soluble coenzyme Q10 in an experimental model of tacrolimus-induced diabetes mellitus
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Quan Y, Luo K, Cui S, Lim SW, Shin YJ, Ko EJ, Kim JH, Chung SJ, Bae SK, Chung BH, Yang CW
- KMID: 2508140
- Korean J Intern Med.
- 2020 Nov;35(6):1443-1456.
- doi: 10.3904/kjim.2019.269
Background/Aims: Coenzyme Q10 (CoQ10) has antioxidant effects and is commercially available and marketed extensively. However, due to its low bioavailability, its effects are still controversial. We developed a water-soluble CoQ10-based... -
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- Shen-Kang protects against tacrolimus-induced renal injury
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Zhang LY, Jin J, Luo K, Piao SG, Zheng HL, Jin JZ, Lim SW, Choi BS, Yang CW, Li C
- KMID: 2457031
- Korean J Intern Med.
- 2019 Sep;34(5):1078-1090.
- doi: 10.3904/kjim.2017.276
BACKGROUND/AIMS: Evidence suggests that Shen-Kang (SK), a traditional Chinese herbal medicine, protects against various types of renal injury. In this study, we evaluated whether SK treatment confers renoprotection in a... -
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- Water-soluble coenzyme Q10 provides better protection than lipid-soluble coenzyme Q10 in a rat model of chronic tacrolimus nephropathy
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Cui S, Luo K, Quan Y, Lim SW, Shin YJ, Lee KE, Kim HL, Ko EJ, Kim JH, Chung SJ, Bae SK, Chung BH, Yang CW
- KMID: 2517812
- Korean J Intern Med.
- 2021 Jul;36(4):949-961.
- doi: 10.3904/kjim.2020.211
Background/Aims: Coenzyme Q10 (CoQ10), is a promising antioxidant; however, low bioavailability owing to lipid-solubility is a limiting factor. We developed water-soluble CoQ10 (CoQ10-W) and compared its effects with conventional lipid-soluble... -
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