Int J Stem Cells.  2020 Nov;13(3):290-304. 10.15283/ijsc20082.

The Progress and Clinical Application of Breast Cancer Organoids

• Yu J
• Huang W

• KMID: 2508903
• DOI: http://doi.org/10.15283/ijsc20082

Abstract

Breast cancer is the malignant tumor with the highest incidence in women. Nowadays, the objects in vitro of models of this disease are mainly from breast cancer cell lines and patient-derived patient-derived xenograft (PDX). However, there is a significant gap between traditional cell lines and breast cancer solid tumors, meanwhiles, PDX is not highly consistent with patients due to different species. As a techonlogy, obtaining patient-derived tumor cells, combined with three-dimensional culture technology, adding cytokines that promotes the proliferation of breast cancer stem cells and inhibit their apoptosis, breast cancer organoids form a structure in vitro which is similar to tumor in the body. This model can not only study the occurrence and envolution of breast cancer, but is more prominent in clinical application. screening drugs by high-throughput, personalized treatment, textingtoxicity and immunotherapy. This article will review the breast cancer organoids, in evolution, source, culture system and clinical applications.

Keyword

Breast cancer; Tumor organoids; Cytokines; Clinical applications