Int Neurourol J.
2019 Nov;23(Suppl 2):S63-S71. 10.5213/inj.1938226.113.
Inflammation as the Potential Basis in Depression
- Affiliations
-
- 1Department of Gerontology, Kyung Hee University Graduate School of East-West Medical Science, Yongin, Korea.
- 2Department of Animal Science and Technology, Konkuk University, Seoul, Korea. hhong58@konkuk.ac.kr
- KMID: 2467314
- DOI: http://doi.org/10.5213/inj.1938226.113
Abstract
- There is growing evidence of the association between inflammation and stress-related disorders including depression. The positive correlation between the increased levels of inflammatory cytokines observed in patients with other diseases and the byproduct of the depressive symptoms may be caused by chronic stress. Increased neuroinflammatory responses are capable of activating microglia and astrocytes, which leads to release pro-inflammatory cytokines. Moreover, elevated levels of inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 are causally related to various aspects of depression such as the behavioral symptomatology. Eventually, these elevated cytokines aggravate and propagate neuroinflammation, impairing brain functions. Thus, activated astrocytes and microglia may be potential mediators in neuroinflammatory processes contributing to the development of depression.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Stress, Inflammation and Neurogenesis in Major Depression
- Galanin's implications for post-stroke improvement
- Plasminogen Activator Inhibitor-1: Potential Inflammatory Marker in Late-life Depression
- Where is the Mechanistic Target of Rapamycin Signaling Pathway in Depression?
- Effects of Brilliant Blue G on Serum Tumor Necrosis Factor-alpha Levels and Depression-like Behavior in Mice after Lipopolysaccharide Administration
