Anat Cell Biol.  2016 Dec;49(4):223-230. 10.5115/acb.2016.49.4.223.

Galanin's implications for post-stroke improvement

Affiliations
  • 1Department of Biomedical Sciences, Center for Creative Biomedical Scientists at Chonnam National University, Gwangju, Korea.
  • 2Human Life Research Center, Dong-A University, Busan, Korea. oykim@dau.ac.kr
  • 3Department of Food Science and Nutrition, Dong-A University, Brain Busan 21, Busan, Korea.

Abstract

Stroke leads to a variety of pathophysiological conditions such as ischemic infarct, cerebral inflammation, neuronal damage, cognitive decline, and depression. Many endeavors have been tried to find the therapeutic solutions to attenuate severe neuropathogenesis after stroke. Several studies have reported that a decrease in the neuropeptide regulator "╦ťgalanin' is associated with neuronal loss, learning and memory dysfunctions, and depression following a stroke. The present review summarized recent evidences on the function and the therapeutic potential of galanin in post-ischemic stroke to provide a further understanding of galanin's role. Hence, we suggest that galanin needs to be considered as a therapeutic factor in the alleviation of post-stroke pathologies.

Keyword

Galanin; Post-stroke; Depression; Inflammation; Cognitive decline

MeSH Terms

Depression
Galanin
Inflammation
Learning
Memory
Neurons
Neuropeptides
Pathology
Stroke
Galanin
Neuropeptides
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