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The Interaction of Inflammatory Markers and Alcohol-Use on Cognitive Function in Korean Male Firefighters

Yun JA, Jeong KS, Ahn YS, Han Y, Choi KS

Objective Cognitive functions have been shown to become impaired due to alcoholism. Recently, neuroinflammation gained attention for playing a role in the neurotoxic effect of alcohol. However, there is limited...
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Depression and APOEε4 Status in Individuals with Subjective Cognitive Decline: A Meta-Analysis

Huang Yp, Xue Jj, Li C, Chen X, Fu Hj, Fei T, Bi Px

Objective To evaluate the associative role of depression and apolipoprotein E epsilon 4 allele (APOEε4) in subjective cognitive decline (SCD) and its progression to objective cognitive decline. Methods After literature search...
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A Validation Study of the Inbrain CST: a Tablet Computer-based Cognitive Screening Test for Elderly People with Cognitive Impairment

Chin J, Kim DE, Lee H, Yun J, Lee BH, Park J, Yeom J, Shin DS, Na DL

Background: Computerized versions of cognitive screening test could have advantages over pencil-and-paper versions by eliminating rater-dependent factors and saving the time required to score the tests and report the results....
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Efficacies of Cognitive Interventions in the Elderly with Subjective Cognitive Decline: A Prospective, Three-Arm, Controlled Trial

Hong YJ, Lee JH, Choi EJ, Han N, Kim JE, Park SH, Kim HJ, Kang DW

Background and Purpose A cognitive intervention (CI) is thought to improve cognition and delay cognitive decline via neuronal plasticity and cognitive resilience. Subjective cognitive decline (SCD) might be the first symptomatic...
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Prediction of Alzheimer's Pathological Changes in Subjective Cognitive Decline Using the Self-report Questionnaire and Neuroimaging Biomarkers

Hong YJ, Park KW, Kang DY, Lee JH

BACKGROUND AND PURPOSE: Subjective cognitive decline (SCD) may be the first symptomatic stage of Alzheimer's disease (AD). Hence, a screening tool to characterize the patients' complaints and assess the risk...
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Postoperative delirium

Oh ST, Park JY

Delirium can be defined as an ‘acute brain dysfunction.’ Compared to dementia, which is a disease that deteriorates the brain function chronically, delirium shows very similar symptoms but is mostly...
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Cognitive Decline in Korean Patients with Neurocognitive Disorder due to Traumatic Brain Injury: A Control for Premorbid Intelligence

Hwang KS, Jang SH, Soh MJ, Lee HJ, Lee SY

OBJECTIVE: Previous studies of cognitive decline in patients with neurocognitive disorder due to traumatic brain injury (NCD-TBI) have often failed to control for baseline factors such as premorbid intelligence. The...
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Different Cortical Thinning Patterns Depending on Their Prognosis in Individuals with Subjective Cognitive Decline

Lim EY, Shim YS, Hong YJ, Ryu SY, Cho AH, Yang DW

BACKGROUND AND PURPOSE: Subjective cognitive decline (SCD) may be the first stage corresponding to subtle cognitive changes in patients with Alzheimer's disease (AD) spectrum disorders. We evaluated the differences in...
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The Influence of Body Mass Index at Diagnosis on Cognitive Decline in Parkinson's Disease

Yoo HS, Chung SJ, Lee PH, Sohn YH, Kang SY

BACKGROUND AND PURPOSE: Associations between alterations in body mass index (BMI) and cognitive function have been reported in Parkinson's disease (PD). We investigated whether the BMI at a PD diagnosis...
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The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline

Bang E, Lee B, Park JO, Jang Y, Kim A, Kim S, Shin HS

In recent years, as the aging population grows, aging-induced cognitive impairments including dementia and Alzheimer's disease (AD) have become the biggest challenges for global public health and social care. Therefore,...
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Subjective Cognitive Decline and Alzheimer's Disease Spectrum Disorder

Hong YJ, Lee JH

Subjective cognitive decline (SCD) represents subjective complaints about cognitive decline in the absence of objective impairment in neuropsychological tests. Recently, growing evidence has suggested that SCD might be the first...
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Factors Associated with Cognitive Function in Breast Cancer Patients Complaining Cognitive Decline

Lee SA, Park KM, Kim TH, Lee E

OBJECTIVES: Cognitive complaints are reported frequently after breast cancer treatments. The causes of cognitive decline are multifactorial, a result of the effect of cancer itself, chemotherapy, and psychological factors such...
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The Novel Implication of Androgen in Diabetes-induced Alzheimer's Disease

Song J, Jung C, Kim OY

Alzheimer's disease (AD) is characterized by the accumulation of amyloid beta (Aβ) and the hyperphosphorylation of tau protein in the brain, leading to the increase in inflammation and neuronal loss....
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Is It Possible to Delay or Prevent Age-Related Cognitive Decline?

Michel JP

Already in the 90s, Khachaturian stated that postponing dementia onset by five years would decrease the prevalence of the late onset dementia by 50%. After two decades of lack of...
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Visual Hallucinations and Amyloid Deposition in Parkinson's Disease Dementia: A Case Report

Um YH, Kim TW, Jeong JH, Seo HJ, Han JH, Hong SC, Jung WS, Choi WH, Lee CU, Lim HK

Parkinson's disease dementia (PDD) is notorious for its debilitating clinical course and high mortality rates. Consequently, various attempts to investigate predictors of cognitive decline in Parkinson's disease (PD) have been...
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Association of Body Mass Index and Cognitive Function in Alzheimer's Disease and Mild Cognitive Impairment

Lim EJ, Lee KJ, Kim H

OBJECTIVES: This study analyzed the differences of body mass index(BMI) in Korean patients with Alzheimer's diseases(AD), Mild Cognitive Impairment(MCI), and healthy controls to verify whether low BMI is associated with...
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Galanin's implications for post-stroke improvement

Song J, Kim OY

Stroke leads to a variety of pathophysiological conditions such as ischemic infarct, cerebral inflammation, neuronal damage, cognitive decline, and depression. Many endeavors have been tried to find the therapeutic solutions...
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Radial Maze Test in a Mouse Model of Noise-Induced Hearing Loss

Park SY, Back SA, Sikandaner H, Yeo SW, Park SN

BACKGROUND AND OBJECTIVES: Hearing loss has been hypothesized to contribute to cognitive decline in the elderly. However, earlier studies yielded conflicting results, and the causal relationship has not been elucidated...
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Reduced Gray Matter Volume in Subjective Cognitive Decline: A Voxel-Based Morphometric Study

Choi Y, Yoon BN, Choi SH, Lim MK, Kim HJ, Yang DW

BACKGROUND AND PURPOSE: Subjective cognitive decline has been proposed as a potential indicator of the preclinical state of Alzheimer's disease (AD). The results of the studies of cortical atrophy on...
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The Relationship between Cognitive Decline Elderly People and Blood Metal Levels : A Systematic Review

Woo ES, Lee YH, Lee SK, Park JH, Lee DW

  • KMID: 1450564
  • J Korean Geriatr Psychiatry.
  • 2011 Dec;15(2):80-90.
OBJECTIVES: There have been several previous studies that the pathology of Alzheimer's disease (AD) might be in part caused or exacerbated by metals. But inconsistent results are often seen in...
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