- Innate Lymphoid Cells in the Airways: Their Functions and Regulators
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Orimo K, Saito H, Matsumoto , Morita H
- KMID: 2471224
- Allergy Asthma Immunol Res.
- 2020 May;12(3):381-398.
- doi: 10.4168/aair.2020.12.3.381
Since the airways are constantly exposed to various pathogens and foreign antigens, various kinds of cells in the airways—including structural cells and immune cells—interact to form a precise defense system... -
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- Characteristics of Pruritus according to Morphological Phenotype of Psoriasis and Association with Neuropeptides and Interleukin-31
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Park SM, Kim GW, Kim HS, Ko HC, Kim MB, Kim BS
- KMID: 2467194
- Ann Dermatol.
- 2020 Feb;32(1):1-7.
- doi: 10.5021/ad.2020.32.1.1
BACKGROUND: Pruritus is a common symptom in psoriasis. However, few studies have assessed the characteristics of pruritus according to morphological phenotypes of psoriasis. OBJECTIVE: To investigate the characteristics of pruritus according... -
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- Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells
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Moon D, Yoon SP, Jang HS, Noh MR, Ha L, Padanilam , Kim J
- KMID: 2467465
- Anat Biol Anthropol.
- 2019 Dec;32(4):121-128.
- doi: 10.11637/aba.2019.32.4.121
Calcitonin gene-related peptide (CGRP) is the most abundant neuropeptide in primary afferent sensory neurons. Exogenous CGRP can induce cell death in kidney tubular cells. The objective of this study was... -
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- Mechanisms of action and clinical applications of anti-obesity drugs currently available in Korea
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Kim KK
- KMID: 2462242
- J Korean Med Assoc.
- 2019 Nov;62(11):588-597.
- doi: 10.5124/jkma.2019.62.11.588
Over the last 5 years, the Korean Ministry of Food and Drug Safety has approved four anti-obesity drugs for long-term weight management. In this review, the mechanisms of action and... -
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- Role of nociceptin/orphanin FQ and nociceptin opioid peptide receptor in depression and antidepressant effects of nociceptin opioid peptide receptor antagonists
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Park JY, Chae S, Kim CS, Kim YJ, Yi HJ, Han E, Joo Y, Hong S, Yun JW, Kim H, Shin KH
- KMID: 2461036
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):427-448.
- doi: 10.4196/kjpp.2019.23.6.427
Nociceptin/orphanin FQ (N/OFQ) and its receptor, nociceptin opioid peptide (NOP) receptor, are localized in brain areas implicated in depression including the amygdala, bed nucleus of the stria terminalis, habenula, and... -
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- Learning and Oxytocin
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Chung YI, Lee BD, Lee YM
- KMID: 2465999
- J Korean Soc Biol Ther Psychiatry.
- 2019 Oct;25(3):192-204.
- doi: 10.0000/jksbtp.2019.25.3.192
Neuropeptide oxytocin serves as a neuromodulator in the brain and as a hormone in the body. Oxytocin as a hypothalamic hormone causes contractions during the second and third stages of... -
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- Short-term Haze Exposure Predisposes Healthy Volunteers to Nasal Inflammation
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Xian M, Wang K, Lou H, Wang Y, Zhang L, Wang C
- KMID: 2452754
- Allergy Asthma Immunol Res.
- 2019 Sep;11(5):632-643.
- doi: 10.4168/aair.2019.11.5.632
PURPOSE: This study aimed to investigate the impact of short-term haze exposure on nasal inflammation in healthy volunteers. METHODS: Thirty-three healthy university students were assessed for nasal symptoms, nasal patency, upper... -
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- Neuropeptides Profile and Increased Innervation in Becker's Nevus
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Kim JS, Park MJ, Kang HY, Hong SP, Park BC, Kim MH
- KMID: 2439061
- Ann Dermatol.
- 2019 Apr;31(2):154-163.
- doi: 10.5021/ad.2019.31.2.154
BACKGROUND: Melanocytes are derived from neural crest, and various pigmentary disorders may accompany abnormalities in nerve system or develop following dermatome, suggesting that melanocyte and pigmentation may be closely related... -
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- A Novel Bio-Psychosocial-Behavioral Treatment Model of Panic Disorder
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Park SC, Kim YK
- KMID: 2438154
- Psychiatry Investig.
- 2019 Jan;16(1):4-15.
- doi: 10.30773/pi.2018.08.21.1
To conceptualize a novel bio-psychosocial-behavioral treatment model of panic disorder (PD), it is necessary to completely integrate behavioral, psychophysiological, neurobiological, and genetic data. Molecular genetic research on PD is specifically... -
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- Comparison of Angiogenic Activities of Three Neuropeptides, Substance P, Secretoneurin, and Neuropeptide Y Using Myocardial Infarction
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Lee J, Song M, Kim J, Park Y
- KMID: 2418105
- Tissue Eng Regen Med.
- 2018 Aug;15(4):493-502.
- doi: 10.1007/s13770-018-0134-x
BACKGROUND: The interplay between neurogenesis and angiogenesis is crucial during the development mediated by neuro-angiogenic morphogens. In particular, the angiogenic activity of neuropeptides and their role in tissue regeneration have... -
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- Capsaicin-Sensitive Sensory Nerves Indirectly Modulate Motor Function of the Urinary Bladder
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Chang HH, Chang SJ, Hsieh CH, Hsu CK, Yang SS
- KMID: 2417780
- Int Neurourol J.
- 2018 Jun;22(2):83-89.
- doi: 10.5213/inj.1836078.039
PURPOSE: The urinary bladder (UB) is innervated by both sensory and autonomic nerves. Recent studies have shown that sensory neuropeptides induced contractions in the detrusor muscle. Therefore, in a mouse... -
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- 4-hydroxy-3-methoxycinnamic acid regulates orexigenic peptides and hepatic glucose homeostasis through phosphorylation of FoxO1
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Kinyua AW, Ko CM, Doan KV, Yang DJ, Huynh MK, Moh SH, Choi YH, Kim KW
- KMID: 2440019
- Exp Mol Med.
- 2018 Feb;50(2):e437.
- doi: 10.1038/emm.2017.253
4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) is known to have numerous beneficial health effects, including anti-obesity and anti-hyperglycemic properties. However, the molecular networks that modulate the beneficial FA-induced metabolic effects have... -
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- Association between Serum Dipeptidyl Peptidase-4 Concentration and Obesity-related Factors in Health Screen Examinees
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Lee JY, Jang BK, Song MK, Kim HS, Kim MK
- KMID: 2392944
- J Obes Metab Syndr.
- 2017 Sep;26(3):188-196.
- doi: 10.7570/jomes.2017.26.3.188
BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) is an aminopeptidase that inhibits the enzymatic degradation of glucagon-like peptide-1, glucose-dependent insulinotropic polypeptides, neuropeptides, and various chemokines. Recent studies reported that serum DPP-4 concentration is... -
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- The roles of mast cells in allergic inflammation and mast cell-related disorders
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Kim HK
- KMID: 2392399
- Allergy Asthma Respir Dis.
- 2017 Sep;5(5):248-255.
- doi: 10.4168/aard.2017.5.5.248
Mast cells, which are major effector cells in allergic reactions, are found in the perivascular spaces of most tissues and contain pro-inflammatory and vasoactive mediators. These mediators are released after... -
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- Inhibiting Vascular Endothelial Growth Factor in Injured Intervertebral Discs Attenuates Pain-Related Neuropeptide Expression in Dorsal Root Ganglia in Rats
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Sato J, Inage K, Miyagi M, Sakuma Y, Yamauchi K, Koda M, Furuya T, Nakamura J, Suzuki M, Kubota G, Oikawa Y, Sainoh T, Fujimoto K, Shiga Y, Abe K, Kanamoto H, Inoue M, Kinoshita , Norimoto M, Umimura T, Takahashi , Ohtori S, Orita S
- KMID: 2387660
- Asian Spine J.
- 2017 Aug;11(4):556-561.
- doi: 10.4184/asj.2017.11.4.556
STUDY DESIGN: An experimental animal study. PURPOSE: To evaluate effects of anti-vascular endothelial growth factor (VEGF) on the content and distribution of the calcitonin gene-related peptide (CGRP) in the dorsal ganglia... -
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- Levodropropizine-Induced Anaphylaxis: Case Series and Literature Review
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Song JW, Jang YS, Jung MC, Kim JH, Choi JH, Park S, Hwang YI, Jang SH, Jung KS
- KMID: 2371729
- Allergy Asthma Immunol Res.
- 2017 May;9(3):278-280.
- doi: 10.4168/aair.2017.9.3.278
Levodropropizine is commonly used as an antitussive drug for acute and chronic cough. It is a non-opioid agent with peripheral antitussive action via the modulation of sensory neuropeptide levels in... -
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- Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic
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Jin P, Yin F, Huang L, Zheng L, Zhao J, Zhang X
- KMID: 2382703
- Exp Mol Med.
- 2017 Apr;49(4):e312.
- doi: 10.1038/emm.2016.173
Neuro-osteological interactions have an important role in the regulation of bone metabolism and regeneration. Neuropeptides combined with porous biphasic calcium phosphates (BCP) using protein adsorption may contribute to the acceleration... -
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- Evolutionary and Comparative Genomics to Drive Rational Drug Design, with Particular Focus on Neuropeptide Seven-Transmembrane Receptors
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Furlong M, Seong JY
- KMID: 2367619
- Biomol Ther.
- 2017 Jan;25(1):57-68.
- doi: 10.4062/biomolther.2016.199
Seven transmembrane receptors (7TMRs), also known as G protein-coupled receptors, are popular targets of drug development, particularly 7TMR systems that are activated by peptide ligands. Although many pharmaceutical drugs have... -
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- Galanin's implications for post-stroke improvement
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Song J, Kim OY
- KMID: 2365551
- Anat Cell Biol.
- 2016 Dec;49(4):223-230.
- doi: 10.5115/acb.2016.49.4.223
Stroke leads to a variety of pathophysiological conditions such as ischemic infarct, cerebral inflammation, neuronal damage, cognitive decline, and depression. Many endeavors have been tried to find the therapeutic solutions... -
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- Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors
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Kim TK, Han PL
- KMID: 2362827
- Exp Neurobiol.
- 2016 Dec;25(6):307-317.
- doi: 10.5607/en.2016.25.6.307
Chronic stress induces changes in neuronal functions in specific brain regions regulating sociability and mood-related behaviors. Recently we reported that stress-induced persistent upregulation of the neuropeptides orexin and melanin-concentrating hormone... -
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