Korean J Anat.
2009 Sep;42(3):197-207.
Study of Cutaneous Neuropeptides-induced Mast Cell Activation
- Affiliations
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- 1Department of Plastic and Reconstructive Surgery, College of Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Korea.
- 2Department of Anatomy, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756, Korea.
- 3Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk 561-756, Korea. asch@chonbuk.ac.kr
Abstract
- Neuropeptides are widely distributed throughout skin, gastrointestinal tracts, and nervous and immune systems. Neuropeptides act to mediate the vasodilation and induce mast cell activation in humans and rats in vitro. However, the mechanism of the cutaneous neuropeptides-induced mast cell activation and the extent of the vascular permeability by cutaneous neuropeptides are not fully understood. This issue was investigated by the injecting six cutaneous neuropeptides-atrial natriuretic peptide, calcitonin gene-related peptide, neuropeptide Y, somatostatin, substance P and vasoactive intestinal peptide-into the skin of rats and by treatment of six cutaneous neuropeptides in rat peritoneal mast cell (RPMC) in vitro. All of the cutaneous neuropeptides increased the significant vascular permeability by the injection into the back skin of normal rats. All of the cutaneous neuropeptides also induced the mast cell degranulation and the histamine release from RPMCs, in a dose-dependent pattern, and increased the calcium uptake and decreased the level of cAMP of RPMCs in vitro. The effects of cutaneous neuropeptides on the vascular permeability and mast cell activation were inhibited by mast cell stabilization agent, disodium cromoglycate. These findings show that cutaneous neuropeptides can induce the mast cell activation by not only increasing the calcium uptake and decreasing the level of cAMP in RPMCs, but also the increment of vascular permeability in the skin of rats.
MeSH Terms
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Animals
Calcitonin Gene-Related Peptide
Calcium
Capillary Permeability
Cromolyn Sodium
Gastrointestinal Tract
Histamine
Histamine Release
Humans
Immune System
Mast Cells
Neuropeptide Y
Neuropeptides
Rats
Skin
Somatostatin
Substance P
Vasodilation
Calcitonin Gene-Related Peptide
Calcium
Cromolyn Sodium
Histamine
Neuropeptide Y
Neuropeptides
Somatostatin
Substance P
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