Korean J Phys Anthropol.  2004 Mar;17(1):19-30.

Inhibitory Effect of Corni fructus on Compound 48/80-induced Mast Cell Activation and Vascular Permeability

• Lim JM
• Li GZ
• Chai OH
• Song CH

Abstract

The fruit of Corni fructus (CF), a perennial herb, is believed to have anti-allergy effects, but its mechanism is unknown. The purpose of this study is to investigate the inhibitory effect of CF on compound 48/80-induced mast cell activation. For this, the effects of CF on the degranulation, the histamine release, the calcium influx and the change of the intracellular cAMP levels of rat peritoneal mast cells (RPMC) and influences of CF on the compound 48/80-induced cutaneous reaction were studied. The results were as follows; the compound 48/80-induced degranulation, intracelluar calcium influx and histamine release of RPMC was significantly inhibited by pretreatment with CF, the compound 48/80-induced cAMP level of RPMC were significantly increased by pretreatment with CF, CF significantly inhibited compound 48/80-induced vascular permeability of rat cutaneous tissue. From the above results, it is suggested that CF contains some substances which inhibit the compound 48/80-induced vascular permeability and mast cell activation.

Keyword

Mast cell; Corni fructus; Compound 48/80; Histmaine; Calcium; cAMP

MeSH Terms

Animals
Calcium
Capillary Permeability*
Cornus*
Fruit
Histamine Release
Mast Cells*
Rats
Calcium