Pediatr Infect Vaccine.  2015 Aug;22(2):75-80. 10.14776/piv.2015.22.2.75.

Stenotrophomonas maltophilia and Ventilator-Associated Pneumonia in Critically Ill Pediatric Patients: a Retrospective Analysis at a Single Center

• Lee BK
• Choi SH
• Kim SJ
• Cho JB
• Ae H
• Yoo SY
• Kim JH
• Lee NY
• Kim YJ

• KMID: 2465251
• DOI: http://doi.org/10.14776/piv.2015.22.2.75

Abstract

PURPOSE
Ventilator-associated pneumonia (VAP) is a serious threat in critically ill pediatric patients. Data regarding Stenotrophomonas maltophilia VAP in pediatric population is limited. We evaluated the clinical data of S. maltophilia associated VAP in critically ill pediatric patients.
METHODS
A retrospective chart review was performed in pediatric patients 18 years old or younger who developed S. maltophilia associated VAP at Samsung Medical Center, Seoul Korea from January 2008 to December 2012.
RESULTS
A total of 31 patients were identified S. maltophilia associated VAP. Median age was 8 months (range, 0.5 month to 16.6 years) and 13 patients were male (40.6%). Underlying illnesses were cardiologic diseases (n=11, 34.4%), hematologic oncologic malignancies (n=7, 25%), neurologic diseases (n=4, 12.5%), pulmonary diseases (n=3, 9.4%), and others (n=4, 12.5%). The median duration of ventilator use before S. maltophilia VAP diagnosis was 14 days (range, 4-256 days). Overall mortality at 30 days was 12.5% (4/32).
CONCLUSIONS
S. maltophilia should be also considered as a possible pathogen for VAP in critically ill pediatric patients. Empiric antibiotic choice should include agents that are active against S. maltophilia in patients who are deteriorating on broad spectrum beta-lactam antimicrobial agents.

Keyword

Stenotrophomonas maltophilia; Pneumonia; Ventilator-Associated; Child

MeSH Terms

Anti-Infective Agents
Child
Critical Illness*
Diagnosis
Humans
Korea
Lung Diseases
Male
Mortality
Pneumonia
Pneumonia, Ventilator-Associated*
Retrospective Studies*
Seoul
Stenotrophomonas maltophilia*
Stenotrophomonas*
Ventilators, Mechanical
Anti-Infective Agents

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