Korean J Physiol Pharmacol.  2019 Sep;23(5):335-344. 10.4196/kjpp.2019.23.5.335.

Effects of caloric restriction on the expression of lipocalin-2 and its receptor in the brown adipose tissue of high-fat diet-fed mice

Affiliations
  • 1Department of Anatomy and Convergence Medical Science, Bio Anti-Aging Medical Research Center, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea. anaroh@gnu.ac.kr
  • 2Department of Thoracic and Cardiovascular Surgery, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52727, Korea.

Abstract

Obesity causes inflammation and impairs thermogenic functions in brown adipose tissue (BAT). The adipokine lipocalin 2 (LCN2) has been implicated in inflammation and obesity. Herein, we investigated the protective effects of caloric restriction (CR) on LCN2-mediated inflammation and oxidative stress in the BAT of high-fat diet (HFD)-fed mice. Mice were fed a HFD for 20 weeks and then either continued on the HFD or subjected to CR for the next 12 weeks. CR led to the browning of the white fat-like phenotype in HFD-fed mice. Increased expressions of LCN2 and its receptor in the BAT of HFD-fed mice were significantly attenuated by CR. Additionally, HFD+CR-fed mice had fewer neutrophils and macrophages expressing LCN2 and iron-positive cells than HFD-fed mice. Further, oxidative stress and mitochondrial fission induced by a HFD were also significantly attenuated by CR. Our findings indicate that the protective effects of CR on inflammation and oxidative stress in the BAT of obese mice may be associated with regulation of LCN2.

Keyword

Brown adipose tissue; Caloric restriction; Lipocalin 2; Obesity

MeSH Terms

Adipokines
Adipose Tissue, Brown*
Animals
Caloric Restriction*
Diet, High-Fat
Inflammation
Lipocalins
Macrophages
Mice*
Mice, Obese
Mitochondrial Dynamics
Neutrophils
Obesity
Oxidative Stress
Phenotype
Adipokines
Lipocalins
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