- Ketamine potentiates neurotoxicity in obese mice
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Chung EY, Yoon JR
- KMID: 2237410
- Korean J Anesthesiol.
- 2008 Oct;55(4):473-478.
- doi: 10.4097/kjae.2008.55.4.473
BACKGROUND: Obesity exacerbates chemically-induced neurodegeneration. N-methyl-D-aspartate (NMDA) antagonists such as ketamine prevent excitotoxicity and are neuroprotective against acute brain injury, but can also be toxic. In low doses they induce... -
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- High Intensity Interval Training Increases Natural Killer Cell Number and Function in Obese Breast Cancer-challenged Mice and Obese Women
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Barra NG, Fan IY, Gillen JB, Chew M, Marcinko K, Steinberg , Gibala MJ, Ashkar AA
- KMID: 2434289
- J Cancer Prev.
- 2017 Dec;22(4):260-266.
- doi: 10.15430/JCP.2017.22.4.260
High intensity interval training (HIIT) boosts natural killer (NK) cell number and activity in normal weight breast cancer patients; however, whether this occurs in obese individuals is not well established.... -
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- Tendency of Death Following Dietary Restriction and Exercise Interventions for Body Weight Control in Diet-induced Obese Mice
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Kim K, Lee W, Ahn N, Hong C, Kim S, Ko J
- KMID: 1461026
- Korean J Obes.
- 2010 Mar;19(1):24-32.
BACKGROUND: Diet-induced obese mice were used as subjects in the course of experimental trial involving weight control. Unusual results were obtained by application of obesity treatment methods as in dietary... -
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- Expression of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma in the lung tissue of obese mice and the effect of rosiglitazone on proinflammatory cytokine expressions in the lung tissue
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Ryu SL, Shim JW, Kim DS, Jung HL, Park MS, Park SH, Lee J, Lee WY, Shim JY
- KMID: 1427931
- Korean J Pediatr.
- 2013 Apr;56(4):151-158.
- doi: 10.3345/kjp.2013.56.4.151
PURPOSE: We investigated the mRNA levels of peroxisome proliferator-activated receptor (PPAR)-alpha, PPAR-gamma, adipokines, and cytokines in the lung tissue of lean and obese mice with and without ovalbumin (OVA) challenge,... -
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- Effects of resveratrol on the insulin signaling pathway of obese mice
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Hong HJ, Kang W, Kim DG, Lee DH, Lee Y, Han CH
- KMID: 1784637
- J Vet Sci.
- 2014 Jun;15(2):179-185.
- doi: 10.4142/jvs.2014.15.2.179
The present study was conducted to investigate the effects of resveratrol on the insulin signaling pathway in the liver of obese mice. To accomplish this, we administered resveratrol to high... -
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- Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice
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Jeong S, Yoon M
- KMID: 756232
- Exp Mol Med.
- 2009 Jun;41(6):397-405.
- doi: 10.3858/emm.2009.41.6.045
Peroxisome proliferator-activated receptor alpha (PPARalpha) activation in rodents is thought to improve insulin sensitivity by decreasing ectopic lipids in non-adipose tissues. Fenofibrate, a lipid-modifying agent that acts as a PPARalpha... -
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- Expression of eotaxin in 3T3-L1 adipocytes and the effects of weight loss in high-fat diet induced obese mice
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Kim HJ, Kim CH, Lee DH, Han MW, Kim MY, Ju JH, Do MS
- KMID: 2313493
- Nutr Res Pract.
- 2011 Feb;5(1):11-19.
Eotaxin is an important inflammatory chemokine in eosinophil chemotaxis and activation and, thus, is implicated in asthma. Recently, obesity was associated with an increased prevalence of asthma, but the relationship... -
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- Impact of High Fat Diet-induced Obesity on the Plasma Levels of Monoamine Neurotransmitters in C57BL/6 Mice
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Kim M, Bae S, Lim KM
- KMID: 2170666
- Biomol Ther.
- 2013 Nov;21(6):476-480.
Obesity is one of the most serious health problems in developed countries. It negatively affects diverse aspects of human wellbeing. Of these, a relationship between obesity and depression is widely... -
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- Effects of Voluntary Running-Wheel Exercise on Insulin, Oxidative Stress and Advanced Glycation End Products in High-Fat Diet-Induced Obese Mice
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Kang DW, Kim SM, Jeon JY
- KMID: 2271154
- Korean J Obes.
- 2015 Mar;24(1):59-62.
- doi: 10.7570/kjo.2015.24.1.59
BACKGROUND: Obesity-induced insulin resistance is an important risk factor for type 2 diabetes and cardiovascular disease. However, as potential mechanisms of increased insulin, how oxidative stress (OS) advanced glycation end-products... -
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- Obesity-Induced Peritoneal Dissemination of Ovarian Cancer and Dominant Recruitment of Macrophages in Ascites
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Ignacio RM, Lee ES, Wilson AJ, Beeghly-Fadiel A, Whalen MM, Son DS
- KMID: 2429839
- Immune Netw.
- 2018 Dec;18(6):e47.
- doi: 10.4110/in.2018.18.e47
One-fifth of cancer deaths are associated with obesity. Because the molecular mechanisms by which obesity affects the progression of ovarian cancer (OC) are poorly understood, we investigated if obesity could... -
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- The anti-obesity effect of Lethariella cladonioides in 3T3-L1 cells and obese mice
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Sung JH, Chon JW, Lee MA, Park JK, Woo JT, Park YK
- KMID: 2313557
- Nutr Res Pract.
- 2011 Dec;5(6):503-510.
The aim of this study was to investigate whether a water extract of L. cladonioides (LC) has an anti-obesity effect in 3T3-L1 cells and obese mice. Treatment of differentiated 3T3-L1... -
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- Anti-inflammatory and anti-diabetic effects of brown seaweeds in high-fat diet-induced obese mice
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Oh JH, Kim J, Lee Y
- KMID: 2313899
- Nutr Res Pract.
- 2016 Feb;10(1):42-48.
- doi: 10.4162/nrp.2016.10.1.42
BACKGROUND/OBJECTIVES: Seaweeds have been reported to have various health beneficial effects. In this study, we investigated the potential anti-obesity and anti-inflammatory effects of four types of domestic brown seaweeds in... -
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- The Inhibitory Effect of Quercetin on Adipose Tissue Inflammation in Mice Fed on a High-fat Diet
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Kim CS, Yu R
- KMID: 2271127
- Korean J Obes.
- 2014 Sep;23(3):170-178.
- doi: 10.7570/kjo.2014.23.3.170
BACKGROUND: Obesity-induced adipose inflammation contributes to the development of metabolic disorders such as insulin resistance and type 2 diabetes. In this study, we investigated whether quercetin, a naturally occurring phytochemical,... -
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- Is Obesity One of Physiological Factors which Exert Influenza Virus-induced Pathology and Vaccine Efficacy?
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Cho W, Nam JH
- KMID: 1726972
- J Bacteriol Virol.
- 2014 Sep;44(3):226-235.
- doi: 10.4167/jbv.2014.44.3.226
Obesity has been considered a risk factor for infectious diseases including the influenza virus. Most epidemiological investigations indicated that obesity is connected to the severity of influenza, although there are... -
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- The Effects of the Sasa Borealis Leaves Extract on Plasma Adiponectin, Resistin, C-Reactive Protein and Homocysteine Levels in High Fat Diet-Induced Obese C57/BL6J Mice
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Kim EY, Jung EY, Lim HS, Heo YR
- KMID: 2260082
- Korean J Nutr.
- 2007 Jun;40(4):303-311.
As obesity is known to be related to hyperlipidemia, diabetes and coronary heart disease, and other chronic diseases, many researches have focused on functional food materials showing anti-obesity activity. The... -
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- Capsanthin Inhibits both Adipogenesis in 3T3-L1 Preadipocytes and Weight Gain in High-Fat Diet-Induced Obese Mice
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Jo SJ, Kim JW, Choi HO, Kim JH, Kim HJ, Woo SH, Han BH
- KMID: 2378812
- Biomol Ther.
- 2017 May;25(3):329-336.
- doi: 10.4062/biomolther.2017.048
Adipogenesis in murine preadipocyte 3T3L-1 has been used as a model system to study anti-obese bioactive molecules. During adipogenesis in 3T3-L1 preadipocytes, we found that capsanthin inhibited adipogenesis (ICâ‚…â‚€; 2.5... -
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- Anti-hyperlipidemic effect of soybean extract fermented by Bacillus subtilis MORI in db/db mice
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Nam Y, Jung H, Karuppasamy S, Lee JY, Kang KD, Hwang KY, Seong SI, Suh JG
- KMID: 1436709
- Lab Anim Res.
- 2012 Jun;28(2):123-129.
- doi: 10.5625/lar.2012.28.2.123
The purpose of this study was to investigate the anti-hyperlipidemic effect of soy bean extract solution fermented by Bacillus subtilis MORI (BTD-1E) in obese db/db mice. Eight-week-old male db/db mice... -
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- Effects of Inonotus Obliqua Extract on Blood Glucose Levels in Genetically Diabetic Mice
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Hong H
- KMID: 2260570
- Korean J Nutr.
- 2007 Oct;40(7):601-605.
This study investigated the therapeutic effects of Inonotus obliqua extract on blood glucose, insulin, and other biochemical parameters in genetically diabetic mice (C57BL/KsJ-m+/+Lepr(db)). The mice were divided into four groups... -
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- Effects of caloric restriction on the expression of lipocalin-2 and its receptor in the brown adipose tissue of high-fat diet-fed mice
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Park KA, Jin Z, An HS, Lee JY, Jeong EA, Choi EB, Kim KE, Shin HJ, Lee JE, Roh GS
- KMID: 2455810
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):335-344.
- doi: 10.4196/kjpp.2019.23.5.335
Obesity causes inflammation and impairs thermogenic functions in brown adipose tissue (BAT). The adipokine lipocalin 2 (LCN2) has been implicated in inflammation and obesity. Herein, we investigated the protective effects... -
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- Metformin Down-regulates TNF-alpha Secretion via Suppression of Scavenger Receptors in Macrophages
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Hyun B, Shin S, Lee A, Lee S, Song Y, Ha NJ, Cho KH, Kim K
- KMID: 2150777
- Immune Netw.
- 2013 Aug;13(4):123-132.
- doi: 10.4110/in.2013.13.4.123
Obesity is consistently increasing in prevalence and can trigger insulin resistance and type 2 diabetes. Many lines of evidence have shown that macrophages play a major role in inflammation associated... -
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