Korean J Obes.
2015 Mar;24(1):59-62. 10.7570/kjo.2015.24.1.59.
Effects of Voluntary Running-Wheel Exercise on Insulin, Oxidative Stress and Advanced Glycation End Products in High-Fat Diet-Induced Obese Mice
- Affiliations
-
- 1Department of Sport and Leisure Studies, Yonsei University, Seoul, Korea. jjeon@yonsei.ac.kr
- KMID: 2271154
- DOI: http://doi.org/10.7570/kjo.2015.24.1.59
Abstract
- BACKGROUND
Obesity-induced insulin resistance is an important risk factor for type 2 diabetes and cardiovascular disease. However, as potential mechanisms of increased insulin, how oxidative stress (OS) advanced glycation end-products (AGEs) can be changed through exercise is not fully understood.
METHODS
A total of 36 C57BL/6 mice were fed either a high-fat diet (HFD; n=19) or chow diet (Chow; n=17) for 7 weeks. The two groups were then divided into voluntary running wheel exercise or no-exercise subgroups each, and the four groups were provided with another 8 weeks of intervention: 1) HFD+exercise (HE; n=11), 2) HFD+no exercise (HN; n=8), 3) Chow+exercise (CE; n=8), and 4) Chow+no exercise (CN; n=9). Body weight, fasting insulin level, and AGEs were measured before and after intervention. ANOVA and Pearson's multiple correlation coefficients were used for statistical analysis using SPSS statistics software version 20.0.
RESULTS
The HE group showed significantly greater weight reduction (P<0.01), while CE and CN did not show significantly different weight reductions between each other. Also, the fasting insulin level was significantly lower in the HE group than in the HN group. The 7-week HFD intervention significantly increased OS and AGEs. However, 8 weeks of exercise did not significantly change OS and AGEs among the groups.
CONCLUSION
The findings of the current study suggest that OS and AGEs may not be related to the pathway of exercise-induced improvement in insulin levels in obese mice.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Voluntary Wheel Running Improves Spatial Learning Memory by Suppressing Inflammation and Apoptosis via Inactivation of Nuclear Factor Kappa B in Brain Inflammation Rats
- Voluntary Wheel Running Exercise Improves Aging-Induced Sarcopenia via Activation of Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α/Fibronectin Type III Domain-Containing Protein 5/Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway
- A comparison of the metabolic effects of treadmill and wheel running exercise in mouse model
- Tendency of Death Following Dietary Restriction and Exercise Interventions for Body Weight Control in Diet-induced Obese Mice
- Effect of Advanced Glycation End Products on Oxidative Stress and Senescence of Trabecular Meshwork Cells
