J Korean Soc Biol Ther Psychiatry.
2019 Feb;25(1):28-35. 10.0000/jksbtp.2019.25.1.28.
The Association of Plasma Inflammatory Cytokines with Dementia and Mild Cognitive Impairment
- Affiliations
-
- 1Department of Psychiatry, Kangdong Sacred Heart Hospital, Seoul, Korea. seongsj01@gmail.com
- KMID: 2454248
- DOI: http://doi.org/10.0000/jksbtp.2019.25.1.28
Abstract
OBJECTIVES
The aim of this study was to investigate the association of plasma levels of inflammatory cytokines with dementia and mild cognitive impairment.
METHODS
We compared serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-6(IL-6), and insulin-like growth factor-1(IGF-I) in patients with dementia(n=8), mild cognitive impairment(MCI, n=15) and normal elderly (n=14). The diagnosis of dementia was made by the Diagnostic Statistical Manual of Mental Disorders-4th edition (DSM-IV). MCI was diagnosed based on the criteria of the National Institute of Aging and Alzheimer Association(NIA-AA) working group.
RESULTS
When compared with normal controls, the levels of TNF-alpha and IL-6 were increased and level of IGF-I was decreased in MCI and dementia. Higher levels of TNF-alpha and IL-6 and lower level of IGF-I were also associated with increased age. However, when adjusted for age, the association between diagnosis and TNF-alpha, Il-6 and IGF-I was not significant.
CONCLUSION
The difference in plasma levels of inflammatory cytokines in dementia and MCI may be associated with aging.
