Korean J Intern Med.  2019 Jan;34(1):108-115. 10.3904/kjim.2017.284.

Association between blood pressure, inflammation and spirometry parameters in chronic obstructive pulmonary disease

• Arslan S
• Yildiz G
• Özdemir L
• Kaysoydu E
• Özdemir B

• KMID: 2452494
• DOI: http://doi.org/10.3904/kjim.2017.284

Abstract

BACKGROUND/AIMS
Many systems including the cardiovascular system (ischemic heart diseases, heart failure, and hypertension) may act as comorbidities that can be seen during the course of chronic obstructive pulmonary disease (COPD). Comorbidities affect the severity and prognosis of COPD negatively. Nearly 25% of patients with COPD die due to cardiovascular diseases. In this study, we aimed to evaluate the relationship between the blood pressure, inflammation, hypoxia, hypercapnia, and the severity of airway obstruction.
METHODS
We included 75 COPD patients in the study with 45 control cases. We evaluated age, sex, body mass index, smoking history, C-reactive protein levels, 24-hour ambulatory blood pressure Holter monitoring, arterial blood gas, and respiratory function tests of the patient and the control groups.
RESULTS
In COPD patients, the night time systolic, diastolic blood pressures and pulse per minute and the mean blood pressures readings were significantly elevated compared to the control group (p < 0.05). In the correlation analysis, night time systolic pressure was associated with all the parameters except forced expiratory volume in 1 second (FEV₁%). Diastolic blood pressure was associated with pH and HCO₃ levels. The mean night time, day time pulse pressures and 24-hour pulse per minute values were also associated with all the parameters except FEV₁%.
CONCLUSIONS
In this study we found that parameters of systolic and diastolic blood pressures and pulse pressures were significantly elevated in COPD patients compared to the control groups. Blood pressure was associated blood gas parameters and inflammation parameters in COPD patients. This, in turn, may cause understanding of the pathophysiology of COPD and its complications.

Keyword

Blood pressure; Pulmonary disease, chronic obstructive; Hypoxia; Inflammation

MeSH Terms

Airway Obstruction
Anoxia
Blood Pressure*
Body Mass Index
C-Reactive Protein
Cardiovascular Diseases
Cardiovascular System
Comorbidity
Electrocardiography, Ambulatory
Forced Expiratory Volume
Heart Diseases
Heart Failure
Humans
Hydrogen-Ion Concentration
Hypercapnia
Inflammation*
Prognosis
Pulmonary Disease, Chronic Obstructive*
Reading
Respiratory Function Tests
Smoke
Smoking
Spirometry*
C-Reactive Protein
Smoke