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CircZNF609 Aggravated Myocardial Ischemia Reperfusion Injury via Mediation of miR-214-3p/PTGS2 Axis

Tang WQ, Yang FR, Chen KM, Yang H, Liu Y, Dou B

Background and Objectives: Circular RNAs were known to play vital role in myocardial ischemia reperfusion injury (MIRI), while the role of CircZNF609 in MIRI remains unclear. This study was aimed to...
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Case Series of Isolated Deep Gray Matter Injuries in Preterm Infants

Hong KT, Shin SH, Choi YH, Kim EK, Kim HS

Hypoxic-ischemic encephalopathy in neonates is an important cause of brain damage that leads to severe neurological sequelae or death. Brain injury patterns on magnetic resonance imaging (MRI) scans are used...
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Analysis of the global gene expression profiles in genomic instability-induced cervical cancer cells

Oh JM

Preserving intact genetic material and delivering it to the next generation are the most significant tasks of living organisms. The integrity of DNA sequences is under constant threat from endogenous...
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The Association of Obstructive Sleep Apnea With Breast Cancer Incidence and Mortality: A Systematic Review and Meta-analysis

Ting Yap DW, Wen Tan NK, Jyn Tan BK, Teo YH, Mien Tan VK, See A, Toh ST

Purpose: Emerging evidence from animal models suggests that intermittent hypoxia due to obstructive sleep apnea (OSA) is a risk factor for breast cancer. Despite their biological plausibility, human epidemiological studies...
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Complex Pathophysiology of Abusive Head Trauma with Poor Neurological Outcome in Infants

Park YS

Abusive head trauma (AHT) in infants, especially acute subdural hematoma, has an extremely poor outcome. The most decisive and important finding is the appearance of a widespread low-density area on...
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A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis

Zeng J, Xiao Xq, Zhou Zy

Purpose Emerging evidence has shown that SKP1-cullin-1-F-box-protein (SCF) E3 ligases contribute to the pathogenesis of different cancers by mediating the ubiquitination and degradation of tumor suppressors. However, the functions of SCF...
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Use of HEAVEN criteria for predicting difficult intubation in the emergency department

Tan NE, Yoong KPY, Yahya HMF

Objective Most airway prediction tools only consider anatomical factors. The HEAVEN criteria incorporate both anatomical and physiological elements, but have never been studied in the emergency department. This study aimed...
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Role of prolyl hydroxylase domain proteins in bone metabolism

Wolf D, Muralidharan A, Mohan S

Cellular metabolism requires dissolved oxygen gas. Because evolutionary refinements have constrained mammalian dissolved oxygen levels, intracellular oxygen sensors are vital for optimizing the bioenergetic and biosynthetic use of dissolved oxygen....
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Enhanced Hypoxia-Associated Genes in Impaired Contractility From Bladder Outlet Obstruction

Kim JH, Yang HJ, Lee HJ, Song YS

Background: Hypoxia damages the bladder wall and contributes to the initiation of bladder dysfunction. The change of hypoxia is not well known in impaired bladder contractility caused by long-term bladder...
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Carbon monoxide releasing molecule-2 suppresses stretchactivated atrial natriuretic peptide secretion by activating largeconductance calcium-activated potassium channels

Li W, Lee SH, Kim SH

Carbon monoxide (CO) is a known gaseous bioactive substance found across a wide array of body systems. The administration of low concentrations of CO has been found to exert an...
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Dimethyloxaloylglycine promotes spermatogenesis activity of spermatogonial stem cells in Bama minipigs

Cao Y, Dai Z, Lao H, Zhao H

Background: The testis has been reported to be a naturally O 2 -deprived organ, dimethyloxaloylglycine (DMOG) can inhibit hypoxia inducible factor-1alpha (HIF-1α) subject to degradation under normal oxygen condition in...
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Vitexin Inhibits Gastric Cancer Growth and Metastasis through HMGB1-mediated Inactivation of the PI3K/ AKT/mTOR/HIF-1α Signaling Pathway

Zhou P, Zheng ZH, Wan T, Wu J, Liao CW, Sun XJ

Purpose: Gastric cancer (GC) has high morbidity and mortality and is a serious threat to public health. The flavonoid compound vitexin is known to exhibit anti-tumor activity. In this study,...
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Correlation-based and feature-driven mutation signature analyses to identify genetic features associated with DNA mutagenic processes in cancer genomes

Jeong HY, Yoo J, Kim H, Kim TM

Mutation signatures represent unique sequence footprints of somatic mutations resulting from specific DNA mutagenic and repair processes. However, their causal associations and the potential utility for genome research remain largely...
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Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1a Signaling Pathway

Liu W, Yuan Y, Liu D

BACKGROUND: Impaired potential of hypoxia-mediated angiogenesis lead poor healing of diabetic wounds. Previous studies have shown that extracellular vesicles from adipose derived stem cells (ADSC-EVs) accelerate wound healing with unelucidated...
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Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia

Zhao C, Guo Y, Wang R, Cheng C, Chen X

The present study aims to investigate the impact of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia. Thirty Sprague–Dawley rats were randomly divided into five...
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Deiodinases and the Three Types of Thyroid Hormone Deiodination Reactions

Sabatino L, Vassalle C, Del Seppia C, Iervasi G

Thyroid hormone (TH) signaling is strictly regulated by iodothyronine deiodinase activity, which both preserves the circulating levels of the biologically active triiodothyronine (T3) and regulates TH homeostasis at the local...
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Secondary hypoxic ischemia alters neurobehavioral outcomes, neuroinflammation, and oxidative stress in mice exposed to controlled cortical impact

Oh SK, Park HJ, Yu GG, Jeong SH, Lee SW, Kim H

Objective Hypoxic ischemia (HI) is a secondary insult that can cause fatal neurologic outcomes after traumatic brain injury (TBI), ranging from mild cognitive deficits to persistent vegetative states. We here...
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Is Biochemical Follow Up Possible in Peripheral Arterial Disease Treatment: Hypoxia Inducible Factor-1 Alpha?

Yücel C, Gürsoy M, Ketenciler S, Tenekeciğil A, Kızıltan F, Kayalar N

Purpose: The hypoxia inducible factor (HIF)-1 is a dimeric protein complex that plays an integral role in the body’s response to hypoxia. This study aimed to analyze the regulation of...
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Effects of carnosine and hypothermia combination therapy on hypoxic-ischemic brain injury in neonatal rats

Byun JC, Lee SR, Kim CS

Background: Carnosine has antioxidative and neuroprotective properties against hypoxic-ischemic (HI) brain injury. Hypothermia is used as a therapeutic tool for HI encephalopathy in newborn infants with perinatal asphyxia. However, the...
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The correlation between the STOP-Bang score and oxygen saturation during spinal anesthesia with dexmedetomidine sedation

Yun M, Kim J, Ryu S, Han S, Shin Y

Background: The STOP-BANG questionnaire is a simple screening tool with high sensitivity for the detection of severe obstructive sleep apnea (OSA). Predicting airway obstruction would allow the safe management of...
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