Genomics Inform.  2019 Mar;17(1):e8. 10.5808/GI.2019.17.1.e8.

Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome

Affiliations
  • 1Department of Medicine, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, Lebanon, NH 03766, USA. ramana181@gmail.com

Abstract

Alveolar type II cells constitute a small fraction of the total lung cell mass. However, they play an important role in many cellular processes including trans-differentiation into type I cells as well as repair of lung injury in response to toxic chemicals and respiratory pathogens. Transcription factors are the regulatory proteins dynamically modulating DNA structure and gene expression. Transcription factor profiling in microarray datasets revealed that several members of AP1, ATF, NF-kB, and C/EBP families involved in diverse responses were expressed in mouse lung type II cells. A transcriptional factor signature consisting of Cebpa, Srebf1, Stat3, Klf5, and Elf3 was identified in lung type II cells, Sox9+ pluripotent lung stem cells as well as in mouse lung development. Identification of the transcription factor profile in mouse lung type II cells will serve as a useful resource and facilitate the integrated analysis of signal transduction pathways and specific gene targets in a variety of physiological conditions.

Keyword

gene signature; lung injury; lung type II cells; microarrays; signal transduction pathways; transcription factor profiling

MeSH Terms

Animals
Dataset
DNA
Gene Expression
Humans
Lung Injury
Lung*
Mice*
NF-kappa B
Signal Transduction*
Stem Cells
Transcription Factors*
Transcriptome*
DNA
NF-kappa B
Transcription Factors
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