J Korean Rheum Assoc.  2008 Mar;15(1):1-10. 10.4078/jkra.2008.15.1.1.

Intracellular Signal Transduction Pathways and Transcription Factors for Osteogenesis

• Im GI

• KMID: 1324504
• DOI: http://doi.org/10.4078/jkra.2008.15.1.1

Abstract

Osteoblastic differentiations of mesenchymal stem cells are controlled by a number of intracellular signal transduction systems and transcription factors. These systems and factors interacts with and cross-talks to one another to complete the process of bone formation. Discovery of these systems has been enabled by gene-targeting techniques. In this brief review, the signal transduction pathways and transcription factors of importance to osteoblastic differentiation are introduced.

Keyword

Signal transduction pathway; Transcription factor; Osteogenesis; Bone

Figure

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  Fig. 1. Canonical pathway of Wnt signaling.

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  Fig. 2. Intracellular signal transduction pathway of BMP signaling.

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  Fig. 3. IHH/PTHrP negative feedback loop in growth plate.

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  Fig. 4. Intracellular signal transduction pathway of Notch.

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  Fig. 5. Run-2 acting as molecular switch in osteogenesis.

Reference

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