J Korean Rheum Assoc.  2003 Mar;10(1):1-8.

Negative Regulation of Intracellular Cytokine Signal Transduction

• Ji JD
• Lee YH
• Song GG

Abstract

Cytokines are secreted proteins and interact with their specific cell surface receptors, triggering intracellular signal transduction pathways that activate a number of genes crucial for the biological functions of cytokines. These cytokine signal transduction pathways are tightly regulated processes. The negative regulations of cytokine signaling are achieved by receptor internalization and degradation, dephosphorylation of signaling intermediates, expression of protein inhibitors such as suppressor of cytokine signaling (SOCS) and protein inhibitors of activated STAT (PIAS). The observation that cytokines are central to the inflammatory and destructive process in several autoimmune diseases suggests that interventions targeting the cytokine intracellular signaling will be a new therapeutic strategy in autoimmune diseases. We review the current knowledge about negative regulation of cytokine signal transduction.

Keyword

Cytokine; Signal transduction; Negative regulation

MeSH Terms

Autoimmune Diseases
Cytokines
Protein Inhibitors of Activated STAT
Receptors, Cell Surface
Signal Transduction*
Social Control, Formal
Cytokines
Protein Inhibitors of Activated STAT
Receptors, Cell Surface