Cancer Res Treat.  2004 Oct;36(5):275-286.

Transcription Factors in the Cellular Signaling Network as Prime Targets of Chemopreventive Phytochemicals

• Surh YJ

Abstract

Accumulating evidence from epidemiologic and laboratory studies support an inverse relationship between a regular consumption of fruits and vegetables and the risk of specific cancers. Numerous phytochemicals derived from edible plants have been reported to possess ability to interfere with a specific stage of carcinogenic process. Multiple mechanisms have been proposed to account for the anti-carcinogenic actions of dietary constituents, but more attention has recently focussed on intracellular signaling cascades as common molecular targets of a wide variety of chemopreventive phytochemicals.

Keyword

Chemoprevention; Phytochemicals; Signal transduction; Cell signaling network; NF- kappa B; AP-1; Mitogen-activated protein kinases; Nrf2; Keap1

MeSH Terms

Chemoprevention
Fruit
Mitogen-Activated Protein Kinases
Phytochemicals*
Plants, Edible
Signal Transduction
Transcription Factor AP-1
Transcription Factors*
Vegetables
Mitogen-Activated Protein Kinases
Transcription Factor AP-1
Transcription Factors