Asian Spine J.  2019 Feb;13(1):155-162. 10.31616/asj.2017.0123.

Elevated Levels of Serum Pentosidine Are Associated with Dropped Head Syndrome in Older Women

Affiliations
  • 1Department of Orthopaedic Surgery, Shimoshizu National Hospital, Yotsukaido, Japan. yawara_eguchi@yahoo.co.jp
  • 2Department of Orthopaedic Surgery, Chiba Qiball Clinic, Chiba, Japan.
  • 3Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
  • 4Department of Orthopaedic Surgery, Eastern Chiba Medical Center, Togane, Japan.

Abstract

STUDY DESIGN: A retrospective observational study was performed. PURPOSE: We investigated the prevalence of sarcopenia in dropped head syndrome (DHS), and the relationship between biochemical markers, including major advanced glycation end products (AGEs), pentosidine, and DHS in older women. OVERVIEW OF LITERATURE: AGEs have been implicated in the pathogenesis of sarcopenia.
METHODS
We studied 13 elderly women with idiopathic DHS (mean age, 77.2 years) and 20 healthy volunteers (mean age, 74.8 years). We used a bioelectrical impedance analyzer to analyze body composition, including appendicular skeletal muscle mass index (SMI; appendicular lean mass [kg]/[height (m)]2). Cervical sagittal plane alignment, including C2-C7 sagittal vertical axis (C2-C7SVA), C2-C7 angle, and C2 slope (C2S), was measured. Biochemical markers, such as serum and urinary pentosidine, serum homocysteine, 1, 25-dihydroxyvitamin D, and 25-hydroxyvitamin D, were measured. The level of each variable was compared between DHS and controls. The relationship between biochemical markers and DHS was examined.
RESULTS
Sarcopenia (SMI < 5.75) was observed at a high prevalence in participants with DHS (77% compared to 22% of healthy controls). Height, weight, femoral bone mineral density, appendicular lean mass, total lean mass, and SMI all had significantly lower values in the DHS group. Serum and urinary pentosidine, and serum homocysteine were significantly higher in the DHS group compared to controls. Analysis of cervical alignment revealed a significant positive correlation of serum pentosidine with C2-C7SVA and C2S.
CONCLUSIONS
Sarcopenia was involved in DHS, and high serum pentosidine levels are associated with severity of DHS in older women.

Keyword

Neck muscles; Sarcopenia; Skeletal muscle; Advanced glycation end products; Homocysteine

MeSH Terms

Aged
Biomarkers
Body Composition
Bone Density
Electric Impedance
Female
Glycosylation End Products, Advanced
Head*
Healthy Volunteers
Homocysteine
Humans
Muscle, Skeletal
Neck Muscles
Observational Study
Prevalence
Retrospective Studies
Sarcopenia
Biomarkers
Glycosylation End Products, Advanced
Homocysteine
Full Text Links
  • ASJ
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error