Endocrinol Metab.  2012 Dec;27(4):289-294. 10.3803/EnM.2012.27.4.289.

The Association between Serum Endogenous Secretory Receptor for Advanced Glycation End Products and Vertebral Fractures in Type 2 Diabetes

• Lee CH
• Lee MK
• Han HJ
• Kim TH
• Lee JH
• Kim SH

• KMID: 1973791
• DOI: http://doi.org/10.3803/EnM.2012.27.4.289

Abstract

BACKGROUND
Patients with type 2 diabetes are known to have an increased risk for osteoporotic fractures compared with non-diabetic subjects. We investigated whether the serum endogenous secretory receptor for advanced glycation end products (esRAGE) or pentosidine was associated with prevalent vertebral fractures in patients with type 2 diabetes.
METHODS
We enrolled 140 patients with type 2 diabetes mellitus (73 men aged 50 or older and 67 postmenopausal women). Lateral X-ray films of the spine revealed prevalent vertebral fractures. The serum concentration of esRAGE and pentosidine were measured.
RESULTS
The mean age of all patients was 66.2 +/- 6.5 years and 22% of patients had prevalent vertebral fractures. Serum pentosidine levels were similar between those with and without vertebral fractures. There were no significant correlations between serum esRAGE levels and age, body mass index, duration of diabetes, and hemoglobin A1c. However, patients with moderate or severe vertebral fractures have a lower esRAGE level compared to those without after adjusting for age and gender (0.33 +/- 0.12 ng/mL vs. 0.24 +/- 0.03 ng/mL, P < 0.05). Logistic regression analysis demonstrated that patients in the lowest tertile of esRAGE had a higher risk of moderate or severe vertebral fractures (odds ratio, 16.6; 95% confidence interval, 1.4-198.5) than patients in the highest tertile.
CONCLUSION
These results revealed that a low esRAGE level was independently associated with moderate or severe vertebral fractures in type 2 diabetic patients.

Keyword

Diabetes mellitus; esRAGE; Osteoporosis; Pentosidine; Spinal fracture

MeSH Terms

Aged
Arginine
Body Mass Index
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glycosylation End Products, Advanced
Hemoglobins
Humans
Logistic Models
Lysine
Male
Osteoporosis
Osteoporotic Fractures
Spinal Fractures
Spine
X-Ray Film
Arginine
Glycosylation End Products, Advanced
Hemoglobins
Lysine

Figure

• 

  Fig. 1. Serum endogenous secretory receptor for advanced glycation end products (esRAGE) concentration in type 2 diabetic patients with or without vertebral fractures after adjusting for age and gender. Patients with moderate or severe vertebral fractures showed significantly lower esRAGE levels compared to those without. ∗Age, gender adjusted P < 0.05.

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