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Increased Carotid Intima-Media Thickness (IMT) in Hyperuricemic Individuals May Be Explained by Hyperhomocysteinemia Associated with Renal Dysfunction: a Cross-Sectional Study

Park JH, Song JS, Choi ST

BACKGROUND: Both hyperuricemia and hyperhomocysteinemia are known as main risk factors of cardiovascular diseases. There has been, however, no report on the relationship between carotid intima-media thickness (IMT) and homocysteine...
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Investigation of the association of idiopathic male infertility with polymorphisms in the methionine synthase (MTR) gene

Tanoomand , Hajibemani A, Abouhamzeh B

OBJECTIVE: Spermatogenesis is a complex process that is regulated by a number of genes, some of which are involved in folate-dependent 1-carbon metabolism. Methionine synthase (encoded by MTR) is a...
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Subacute Combined Degeneration Caused by Nitrous Oxide Intoxication: A Report of Two Cases

Choi C, Kim T, Park KD, Lim OK, Lee JK

We report two cases of subacute combined degeneration (SCD) caused by nitrous oxide (Nâ‚‚O) gas intoxication, which is rarely reported in Korea. Two patients recreationally inhaled Nâ‚‚O gas daily for...
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Association between Homocysteine Levels and Psoriasis: A Meta-Analysis

Kim JE, Lee HJ, Lee JS, Whang KU, Park YL, Lee SY, Kim HJ

BACKGROUND: Psoriasis is a multifactorial disease associated with an increased risk for metabolic syndrome and cardiovascular diseases. Elevated levels of homocysteine (Hcy) are a marker of cardiovascular risk. Several studies...
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Associations of Metabolic Syndrome with Total Testosterone and Homocysteine Levels in Male Korean Workers

Sung SH, Kim NH, Hong SP, Lee JK, Choi SJ

BACKGROUND: Low testosterone is associated with metabolic syndrome (MetS), and homocysteine (Hcy) is elevated in individuals with MetS. We investigated the relationships of total testosterone (TT) and serum Hcy levels...
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Short-Term and Long-Term Effects of Levetiracetam Monotherapy on Homocysteine Metabolism in Children with Epilepsy: A Prospective Study

Attilakos , Paschalidou M, Garoufi A, Tsirouda M, Papadopoulou A, Karalexi M, Dinopoulos A

BACKGROUND AND PURPOSE: Long-term treatment with some older antiepileptic drugs may lead to hyperhomocysteinemia. Levetiracetam (LEV) is a newer broad-spectrum antiepileptic agent whose effects on homocysteine concentrations remain unclear. The...
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Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naïve Patients with Major Depression: A Study in the “Real World” Clinical Practice

De Berardis D, Olivieri L, Rapini G, Di Natale , Serroni N, Fornaro M, Orsolini L, Valchera A, Carano A, Vellante F, Varasano P, Pressanti , Serafini G, Pompili M, Martinotti G, Di Giannantonio M

OBJECTIVE: This study was performed to elucidate relationships between alexithymia, suicide ideation and homocysteine levels in drug-naïve outpatients with major depressive disorder (MDD). METHODS: Sixty seven outpatients with MDD with melancholic...
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Elevated Levels of Serum Pentosidine Are Associated with Dropped Head Syndrome in Older Women

Eguchi Y, Toyoguchi , Inage K, Orita S, Yamauchi K, Suzuki M, Kanamoto H, Abe K, Norimoto M, Umimura T, Koda M, Furuya T, Aoki Y, Takahashi , Ohtori S

STUDY DESIGN: A retrospective observational study was performed. PURPOSE: We investigated the prevalence of sarcopenia in dropped head syndrome (DHS), and the relationship between biochemical markers, including major advanced glycation end...
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The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis

Nozari E, Ghavamzadeh S, Razazian N

Plasma homocysteine level and megaloblastic anemia status are two factors that can affect the quality of life of patients with multiple sclerosis (MS). We conducted this study to determine the...
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Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective

Sidorov E, Sanghera D, Vanamala J

Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis even before a patient arrives to the hospital. Metabolome is one of new technologies that help to find...
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Association between shift work and hyperhomocysteinemia in male workers

Kang D, Kang SK, Choi WJ, Lee SH, Lee JH, Kwak K

BACKGROUND: Shift work is associated with a higher risk of cardiovascular diseases. Here, we sought to assess the relationship between shift work and plasma homocysteine levels. Determining the correlations between...
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The Cutoff Pericardial Adipose Tissue Volume Associated with Metabolic Syndrome

Kim DS, Ok EJ, Choi BH, Joo NS

BACKGROUND: Metabolic syndrome (MS) is a well-known risk factor of cardiovascular diseases that is focused on central obesity. Recent studies have reported the association between pericardial adipose tissue (PAT) volume...
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Childhood Venous Thromboembolism in Yeungnam Region in Korea: Multicenter Study

Lee S, Youn JH, Lim JY, Chueh HW, Lee JM, Suh JK, Kim JY, Yang EJ, Park KM, Lim YT, Park J, Choi EM, Shim YJ, Kim HS, Park SK, Kong SG, Choi EJ, Park ES

BACKGROUND: Venous thromboembolism (VTE) is rare in pediatric patients compared to adults, but it's incidence is gradually increasing. The purpose of this study was to analyze the incidence, risk factors,...
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Age-Related Changes in Sulfur Amino Acid Metabolism in Male C57BL/6 Mice

Jeon JS, Oh JJ, Kwak HC, Yun HY, Kim HC, Kim YM, Oh SJ, Kim SK

Alterations in sulfur amino acid metabolism are associated with an increased risk of a number of common late-life diseases, which raises the possibility that metabolism of sulfur amino acids may...
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Carotid Plaque Stiffness Measured with Supersonic Shear Imaging and Its Correlation with Serum Homocysteine Level in Ischemic Stroke Patients

Shang J, Wang W, Feng J, Luo GG, Dang Y, Sun J, Yang YQ, Ruan LT

OBJECTIVE: To ascertain the feasibility of using shear wave velocity (SWV) in assessing the stiffness of carotid plaque by supersonic shear imaging (SSI) and explore preliminary clinical value for such...
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The Levels of Vitamin D, Vitamin D Receptor, Homocysteine and Complex B Vitamin in Children with Autism Spectrum Disorders

Altun H, Kurutaş E, Şahin N, Güngör O, Fındıklı E

OBJECTIVE: Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome with an increasingly prevalent etiology, yet not fully understood. It has been thought that vitamin D, complex B vitamin levels...
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The Effects of Korean DASH Diet Education Program on Oxidative Stress, Antioxidant Capacity, and Serum Homocysteine Level among Elderly Korean Women

Choi SH, Choi-Kwon , Kwak CS, Lee H

PURPOSE: The purpose of this study was to investigate the effects of the Korean Dietary Approaches to Stop Hypertension (DASH) education program on oxidative stress, antioxidant capacity, and serum homocysteine...
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Effects of folic acid supplementation on serum homocysteine levels, lipid profiles, and vascular parameters in post-menopausal Korean women with type 2 diabetes mellitus

Vijayakumar A, Kim EK, Kim H, Choi YJ, Huh KB, Chang N

BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related...
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Effects of Homocysteine and Hyperglycemia on the Proliferation of Aortic Vascular Smooth Muscle Cells of Obese Type 2 Diabetes Rat

Yoo HJ, Yu SH, Cho YJ, Nam HW, Kang DH

BACKGROUND: The aim of this study was to investigate the role of homocysteine on the proliferation of rat aortic vascular smooth muscle cells (VSMCs) by measuring mitogen-activated protein (MAP) kinase...
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Brain Stem Infarction Due to Basilar Artery Dissection in a Patient with a Parotitis and Hyperhomocysteinemia

Ahn BJ

A 29-year-old man developed sudden dysarthria and right-sided weakness 3 days before admission to hospital. He was diagnosed with parotitis in the emergency room of Soonchunhyang University Gumi Hospital. The...
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