J Korean Ophthalmol Soc.  2016 Mar;57(3):461-467. 10.3341/jkos.2016.57.3.461.

Analysis of Serum Homocysteine and Risk of Coronary Heart Disease in Patients with Pseudoexfoliation Syndrome

• Gu BY
• Chu JH
• Lim SH
• Cha SC

• KMID: 2213248
• DOI: http://doi.org/10.3341/jkos.2016.57.3.461

Abstract

PURPOSE
To investigate levels of serum homocysteine in patients with pseudoexfoliation syndrome and the association between serum homocysteine levels and risk of coronary heart disease.
METHODS
From March 2013 to September 2013, 37 patients with pseudoexfoliation syndrome and 59 age-matched patients (control group) were enrolled in this prospective study. Serum homocysteine levels were compared between the 2 groups. We compared the estimated 10-year risk of coronary heart disease based on Framingham risk score between the 2 groups. Additionally, we analyzed correlations between risk of coronary heart disease and serum homocysteine levels.
RESULTS
The mean homocysteine level of patients with pseudoexfoliation syndrome was significantly higher than the control group (13.3 ± 6.8 µmol/L vs. 10.0 ± 5.2 µmol/L, p = 0.009). The rate of high risk defined as a 10-year coronary heart disease risk >20% in the patients with pseudoexfoliation syndrome was significantly higher than in the control group (21.4% vs. 4.4%, p = 0.048). Correlation between serum homocysteine levels and estimated 10-year risk of coronary heart disease was statistically significant (r = 0.578, p < 0.001).
CONCLUSIONS
Hyperhomocysteinemia and high risk of coronary heart disease were observed in patients with pseudoexfoliation syndrome. Therefore, we suggest efforts to prevent coronary heart disease in pseudoexfoliation syndrome patients with hyperhomocysteinemia are necessary.

Keyword

Coronary heart disease; Exfoliation syndrome; Framingham risk score; Homocysteine; Pseudoexfoliation syndrome

MeSH Terms

Coronary Disease*
Exfoliation Syndrome*
Homocysteine*
Humans
Hyperhomocysteinemia
Prospective Studies
Homocysteine

Figure

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  Figure 1. Correlations between risk of coronary heart disease and serum homocysteine levels. Serum homocysteine levels were positively correlated to Framingham 10-year coronary heart disease risk in all subjects without diabetics (N = 73, r = 0.578, p < 0.001, Pearson's correlation coefficient). CHD = coronary heart disease; XFS = pseudoexfoliation syndrome.

Reference

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