Korean Circ J.  2001 Jun;31(6):560-566. 10.4070/kcj.2001.31.6.560.

The Effects of Serum Homocysteine on the Restenosis after Percutaneous Coronary Intervention

• Park OY
• Jeong MH
• Yun BR
• Lee SR
• Jeong WG
• Lee SH
• Kang KT
• Cho JG
• Suh SP
• Park JC
• Kang JC

• KMID: 2093820
• DOI: http://doi.org/10.4070/kcj.2001.31.6.560

Abstract

BACKGROUND AND OBJECTIVES: Hyperhomocyt(e)inemia is known to be one of independent risk factors for the ischemic heart diseases recently, but the role of hyperhomocysteinemia in restenosis after coronary intervention is unclear. The relationship between plasma homocysteine level and restenosis after coronary intervention was evaluated in Korean patients. MATERIALS AND METHOD: Eighty three patients underwent successful percutaneous coronary intervention (PCI) and follow-up coronary angiography were divided into two groups according to restenosis, and the level of plasma homocysteine was compared between groups with restenosis (n=5, M:F=7:8, 60.6+/-13.5 years) and without restenosis (n=8, M:F=0:8, 60.3+/-12.8 years).
RESULTS
The clinical manifestation, atherosclerosis risk factors except for hypertension, and coronary angiographic findings were not significantly different in patients with or without restenosis(P=S). The value of homocysteine was 9.3+/-3.1 micromol/L in 35 patients with restenosis and 8.4+/-2.5 micromol/L in 48 patients without restenosis(P=S). All of 8 patients whose values of plasma homocysteine were more than 13 micromol/L, had angiographic restenosis. Plasma homocysteine was not an independent risk factor of restenosis by means of logistic regression analysis.
CONCLUSION
Plasma homocysteine is not a potential risk factor of restenosis after percutaneous coronary intervention.

MeSH Terms

Atherosclerosis
Coronary Angiography
Follow-Up Studies
Homocysteine*
Humans
Hyperhomocysteinemia
Hypertension
Logistic Models
Myocardial Ischemia
Percutaneous Coronary Intervention*
Plasma
Risk Factors
Homocysteine