Korean J Pediatr Infect Dis.  1996 Nov;3(2):194-199. 10.14776/kjpid.1996.3.2.194.

A Case of Cryptococcal Lymphadenitis Mimicking Lymphoma

• Kim BM
• Min KS
• Kim JW
• Kim KN
• Ryoo KY

• KMID: 2440443
• DOI: http://doi.org/10.14776/kjpid.1996.3.2.194

Abstract

Cryptococcosis is a rare in normal child and the majority of cases usually occur in patients with defective cell-mediated immunity. Infection is acquired by inhalation of organisms from the environment and disseminated via the blood stream to any organ of the body. We experienced a 7 year old girl who presented with fever, both cervical lymphadenopathy, hepatomegaly under the impression of lymphoma. However lymph node biopsy revealed cryptococcal budding and culture of lymph nodes yielded cryptococcus neoformans. The radiologic finding showed huge, multiple cervical lymph node enlargement spreading to mediastinum and abdomen. The immune fuction in term of T cell, B cell, serum immunoglobulin, complement and neutrophil function tests was normal. The patient was treated with amphotericin B and flucytosine for 6 weeks and responded to the treatment well. We report this case with brief review of the related literatures.

Keyword

Cryptococcal lymphadenitis

MeSH Terms

Abdomen
Amphotericin B
Biopsy
Child
Complement System Proteins
Cryptococcosis
Cryptococcus neoformans
Female
Fever
Flucytosine
Hepatomegaly
Humans
Immunity, Cellular
Immunoglobulins
Inhalation
Lymph Nodes
Lymphadenitis*
Lymphatic Diseases
Lymphoma*
Mediastinum
Neutrophils
Rivers
Amphotericin B
Complement System Proteins
Flucytosine
Immunoglobulins