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An attenuated Salmonella vaccine secreting Lawsonia intracellularis immunogenic antigens confers dual protection against porcine proliferative enteropathy and salmonellosis in a murine model

Park S, Won G, Lee JH

Porcine proliferative enteropathy (PPE) caused by Lawsonia intracellularis (LI) is a global cause for substantial economic losses in the swine industry. Here, we constructed live attenuated Salmonella typhimurium (ST) mutant...
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A long-term subacute sclerosing panencephalitis survivor treated with intraventricular interferon-alpha for 13 years

Kwak M, Yeh HR, Yum MS, Kim HJ, You SJ, Ko TS

Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, and fatal central nervous system disorder resulting from persistent measles virus infection. Long-term data are scarce, with a maximum follow-up period of...
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Incidence and risk factors for herpes zoster after adult liver transplantation

Kim W, Kim S, Oh J, Jeong YJ, Rhu J, Kim KS, Lee J, Choi GS, Kim JM, Joh JW

PURPOSE: Herpes zoster (HZ) is caused by reactivation of the varicella zoster virus, which occurs frequently in liver transplant recipients with impaired cellular immunity. The purpose of this study was...
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Vaccine containing G protein fragment and recombinant baculovirus expressing M2 protein induces protective immunity to respiratory syncytial virus

Jo YM, Kim J, Chang J

PURPOSE: Respiratory syncytial virus (RSV) can cause serious respiratory illnesses such as pneumonia, asthma, and bronchiolitis in infants and elderly or immunocompromised individuals. An RSV vaccine has yet to be...
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Evaluation of Protective Immune Response Induced by a DNA Vaccine Encoding GRA8 against Acute Toxoplasmosis in a Murine Model

Chu JQ, Huang S, Ye W, Fan XY, Huang R, Ye SC, Yu CY, Wu WY, Zhou Y, Zhou W, Lee YH, Quan JH

Toxoplasma gondii is an apicomplexan zoonotic protozoan parasite that infects most species of warm-blooded animals, including humans. The heavy incidence and severe or lethal damage caused by T. gondii infection...
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Association between endotoxin levels in dust from indoor swine housing environments and the immune responses of pigs

Roque K, Shin KM, Jo JH, Lim GD, Song ES, Shin SJ, Gautam R, Lee JH, Kim YG, Cho AR, Kim CY, Kim HJ, Lee MS, Oh HG, Lee BC, Kim JH, Kim KH, Jeong HK, Kim HA, Heo Y

Indoor animal husbandry environments are inevitably contaminated with endotoxins. Endotoxin exposure is associated with various inflammatory illnesses in animals. This cross-sectional study evaluated the relationship between the degree of endotoxin...
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Programmed death-1 (PD-1) expression in cervical intraepithelial neoplasia and its relationship with recurrence after conization

Chang H, Hong JH, Lee JK, Cho HW, Ouh YT, Min KJ, So KA

OBJECTIVE: Impaired local cellular immunity contributes to persistent human papillomavirus (HPV) infection and development of cervical intraepithelial neoplasia (CIN). Programmed death-1 (PD-1) and its ligands PD-ligand-1 (L1) and PD-L2 are...
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The Role of Reactive Oxygen Species in Regulating T Cell-mediated Immunity and Disease

Yarosz EL, Chang CH

T lymphocytes rely on several metabolic processes to produce the high amounts of energy and metabolites needed to drive clonal expansion and the development of effector functions. However, many of...
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Seropositivity of Hepatitis C Virus among Persons affected Leprosy in Korea

Kim JP, Kang KH, Park JM

BACKGROUND: Leprosy is a contagious chronic granulomatous disease and is a disease that is associated with defects in cellular immunity. A high prevalence of hepatitis C virus infection in leprosy...
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Comparison of immunoadjuvant activities of four bursal peptides combined with H9N2 avian influenza virus vaccine

Zhang C, Zhou J, Liu Z, Liu Y, Cai K, Shen T, Liao C, Wang C

The bursa of Fabricius (BF) is a central humoral immune organ unique to birds. Four bursal peptides (BP-I, BP-II, BP-III, and BP-IV) have been isolated and identified from the BF....
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Immunological Prediction of Cytomegalovirus (CMV) Replication Risk in Solid Organ Transplantation Recipients: Approaches for Regulating the Targeted Anti-CMV Prevention Strategies

Han SH

The current cytomegalovirus (CMV) prevention strategies in solid organ transplantation (SOT) recipients have contributed towards overcoming the detrimental effects caused by CMV lytic infection, and improving the long-term success rate...
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Immunogenicity of recombinant Lactobacillus plantarum NC8 expressing goose parvovirus VP2 gene in BALB/c mice

Liu YY, Yang WT, Shi SH, Li YJ, Zhao L, Shi CW, Zhou FY, Jiang YL, Hu JT, Gu W, Yang GL, Wang CF

Goose parvovirus (GPV) continues to be a threat to goose farms and has significant economic effects on the production of geese. Current commercially available vaccines only rarely prevent GPV infection....
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Comparison of humoral and cell-mediated immunity in three different C57BL/6N mouse substrains

Kim HR, Choi JY, Kim KS, Jung YS, Cho JY, Hwang DY, Song HK

Adaptive immunity is a type of immune response mediated by T and B cells, and is important response for immune response amplification and memory. In this study, the adaptive immunologic...
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Use of C57BL/6N mice on the variety of immunological researches

Song HK, Hwang DY

Inbred mice are an essential animal strain for research as they can improve the reproducibility and reliability of study results. The establishment of new inbred lines is continuing, and new...
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Humoral and Cellular Immunogenicity Induced by Avian Influenza A (H7N9) DNA Vaccine in Mice

Choi EJ, Lee HS, Noh JY, Song JY, Cheong HJ, Shin OS, Lee H, Jeong M, Kim WJ

BACKGROUND: In March 2013, human infection with avian influenza A (H7N9) virus emerged in China, causing serious public health concerns and raising the possibility of avian-source pandemic influenza. Thus, the...
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Dendritic Cell Dysfunction in Patients with End-stage Renal Disease

Kim JU, Kim M, Kim S, Nguyen TT, Kim E, Lee S, Kim S, Kim H

End-stage renal disease (ESRD) with immune disorder involves complex interactions between the innate and adaptive immune responses. ESRD is associated with various alterations in immune function such as a reduction...
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Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children

Mexitalia , Dewi YO, Pramono A, Anam MS

PURPOSE: Tuberculosis (TB) remains a problem in the community. TB patients usually experience malnutrition, which is characterized by both decreased body weight (BW) and body fat percentage (BFP). Leptin, an...
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Distinct Effects of Monophosphoryl Lipid A, Oligodeoxynucleotide CpG, and Combination Adjuvants on Modulating Innate and Adaptive Immune Responses to Influenza Vaccination

Ko EJ, Lee YT, Lee Y, Kim KH, Kang SM

Monophosphoryl lipid A (MPL) and oligodeoxynucleotide CpG are toll-like receptor (TLR) 4 and 9 agonist, respectively. Here, we investigated the effects of MPL, CpG, and combination adjuvants on stimulating in...
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Comparison of the Commercial QuantiFERON-CMV and Overlapping Peptide-based ELISPOT Assays for Predicting CMV Infection in Kidney Transplant Recipients

Kwon JS, Kim T, Kim SM, Sung H, Shin S, Kim YH, Shin EC, Kim SH, Han DJ

Cytomegalovirus (CMV) is one of the most important opportunistic infections in transplant recipients. Tests for CMV-specific T cell responses have been proposed to change the current risk stratification strategy using...
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A Study of the Changes of T Helper 17 Cells and Regulatory T Cells in Herpes Zoster

Kim MS, Kim DJ, Na CH, Shin BS

BACKGROUND: Immunosuppression and age-related deficiencies in cell-mediated immunity are important factors for the reactivation of latent varicella-zoster virus (VZV). CD4⁺CD25⁺Foxp3⁺ regulatory T (Treg) cells and T helper 17 (Th17) cells...
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