Ann Dermatol.  1994 Jul;6(2):152-156. 10.5021/ad.1994.6.2.152.

Correlation of Natural Killer(NK) Cell Activity,Antibody Dependent Cellular Cytotoxicity(ADCC), and Serum Zinc Level in Behçet's Disease

• Chung KY
• Bang D
• Lee SH
• Lee ES
• Lee S

• KMID: 2361452
• DOI: http://doi.org/10.5021/ad.1994.6.2.152

Abstract

BACKGROUND
Zinc which is widely used to treat Behcet's disease, is known to be an important modulator in various aspects of immunity including cell mediated immunity (CMI). CMI is suspected of playing a major role in the pathogenesis of Behçet's disease.
OBJECTIVE
This study was done to clarify the relationship of CMI and zinc in Behçet's disease.
METHODS
Serum zinc level, NK cell activity, and ADCC were measured in 83 patients with Behçet's diseade. The results were analyzed using multiple regression analysis.
RESULTS
ADCC and serum zinc level were found to be two significant variables that affect NK cell activity positively and negatively, respectively.
CONCLUSION
Serum zinc is presumed to exert inhibitory effect on NK cell activity but does not affect ADCC in Behçet's disease patients.

Keyword

Behçet's disease; NK cell activity; ADCC; Serum zinc

MeSH Terms

Antibody-Dependent Cell Cytotoxicity
Humans
Immunity, Cellular
Killer Cells, Natural
Zinc*
Zinc