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Conformational Dynamics of Sclerostin-LRP6 Complex Analyzed by HDX-MS

Jeong Y, Kim J, Choi HJ, Chung KY

Sclerostin (SOST), a regulator of bone formation in osteocytes, inhibits the canonical Wnt signaling by interacting with low-density lipoprotein receptor-related protein 5/6 (LRP5/6) to prevent Wnt binding. Loss-of-function mutations of...
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Invasive Cutaneous Squamous Cell Carcinoma Arising from Chronic Hidradenitis Suppurativa: A Case Report of Treatment by Slow Mohs Micrographic Surgery

Lee SJ, Lim JM, Lee SH, Chung KY, Roh MR

Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory condition presenting with painful, deep-seated abscesses and sinus tracts in multifocal locations. Rarely, longstanding inflammation in HS may lead to serious complications,...
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PTEN Promoter Hypermethylation Is Associated with Breslow Thickness in Acral Melanoma on the Heel, Forefoot, and Hallux

Park HS, Kim JH, Cho MY, Chung KY, Roh MR

Background: Acral melanoma occurs on glabrous skin or the nail apparatus and is distinct from ultraviolet-related melanoma due to differing genetic alteration patterns. Although the pathogenesis of acral melanoma is...
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Combined impact of extended criteria donor and cold ischemic time on delayed graft function in deceased donor kidney transplantation

Song SH, Jung D, Chung KY

Background: The most significant complication is delayed graft function (DGF) on deceased donor kidney transplantation (DDKT). Multiple factors belonging to donor, recipient, and transplant procedures have an effect on the...
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Uremic cardiomyopathy may improve with kidney transplantation: a case report

Song SH, Jung D, Chung KY

Background: In patients with chronic kidney disease (CKD), left ventricular (LV) hypertrophy with impaired LV systolic function, which is called uremic cardiomyopathy is often observed. In recent studies, CKD may...
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Questionnaire Investigation of the Treatment History and Characteristics of Patients with Recalcitrant Warts: A Pilot Study

Choi S, Chung KY, Oh BH

  • KMID: 2512391
  • Korean J Dermatol.
  • 2021 Jan;59(1):1-7.
Background: Refractory warts remain unresponsive to a variety of treatment modalities. A questionnaire survey that includes information regarding patients’ symptoms and history can provide a deeper understanding of the discomfort...
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The Effects of Entrance Examination Stress on Oral Health Behavior and Subjective Oral Health in Female High School Students

Chung KY

Background: The purpose of this study is to investigate the effects of entrance exam stress on oral health behaviors and subjective oral health status in female high school students. Methods: A...
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Clinical Outcomes of Immune Checkpoint Blocker Therapy for Malignant Melanoma in Korean Patients: Potential Clinical Implications for a Combination Strategy Involving Radiotherapy

Lee J, Chang JS, Roh MR, Jung M, Lee CK, Oh BH, Chung KY, Koom WS, Shin SJ

Purpose We investigated the clinical efficacy of immune checkpoint blocker (ICB) therapy for metastatic or advanced melanoma in Korean patients. As well, we assessed whether the effects of ICBs can be...
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Hypoalbuminemia and obesity class II are reliable predictors of peri-prosthetic joint infection in patient undergoing elective total knee arthroplasty

Man SLC, Chau WW, Chung KY, Ho KKW

Background:Malnutrition is a common and modifiable risk factor for postoperative complications and adverse outcomes in orthopedics. The purpose of this study was to identify biomarkers of malnutrition in patients undergoing...
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Factors Affecting the Number of Stapler Cartridges in Complete Video-Assisted Thoracoscopic Surgery Lobectomy for Non-small Cell Lung Cancer

Yang YH, Lee e, Lee CY, Kim DJ, Lee JG, Chung KY

Background: Video-assisted thoracoscopic surgery (VATS) lobectomy has become the major surgical option for the treatment of non-small cell lung cancer (NSCLC). Endoscopic instruments such as stapler cartridges are essential for...
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Effects of some commercial calamansi-containing beverages on the enamel surface

Kim EK, Park HR, Chung KY, Choi CH, Jeong SS

OBJECTIVES: The aim of this study was to investigate the effects of some commercial calamansicontaining beverages on the sound surface of bovine teeth as well as the dental erosion inhibitory...
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Complications and outcomes following inguinal lymphadenectomy for malignant melanoma in an Asian population

Lee IA, Kim HJ, Kim E, Lee JY, Lee J, Lee JG, Lee Ck, Shin SJ, Chung KY, Kim MS

Purpose: Melanoma is a potentially fatal cutaneous malignancy and regional lymph node (LN) metastases are the most important predictors of mortality. This study aimed to analyze clinical features and risk...
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L-ascorbic acid induces apoptosis in human laryngeal epidermoid Hep-2 cells by modulating the nuclear factor kappa-light-chain-enhancer of activated B cells/ mitogen-activated protein kinase/Akt signaling pathway

Park JS, Kim YJ, Park SY, Chung KY, Oh SJ, Kim WJ, Jung JY

L-ascorbic acid (L-AA; vitamin C) induces apoptosis in cancer cells. This study aimed to elucidate the molecular mechanisms of L-AA-induced apoptosis in human laryngeal epidermoid carcinoma Hep-2 cells. L-AA suppressed...
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Uremic cardiomyopathy may improve with kidney transplantation: a case report

Song SH, Hong G, Chung KY, Jung D

Background: In patients with chronic kidney disease (CKD), left ventricular (LV) hypertrophy with impaired LV systolic function, which is called uremic cardiomyopathy is often observed. In recent studies, CKD may...
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Risk factors of delayed graft function in deceased donor kidney transplantation

Song SH, Jung D, Chung KY

Background: The most significant complication is delayed graft function (DGF) on deceased donor kidney transplantation (DDKT). Multiple factors belonging to donor, recipient, and transplant procedures have an effect on the development...
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Prospective randomized trial comparing efficacy and safety of intravenous and intra-articular tranexamic acid in total knee arthroplasty

Li MML, Kwok JYY, Chung KY, Cheung KW, Chiu KH, Chau WW, Ho KKW

Background Total knee arthroplasty (TKA) is associated with significant perioperative blood loss and postoperative allogenic blood transfusion. Tranexamic acid (TXA) reversibly blocks lysine binding sites on plasminogen molecules and inhibits plasmin...
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Triple Extramammary Paget’s Disease: A Case Report

Kim J, Kim S, Oh BH, Chung KY

  • KMID: 2501400
  • Korean J Dermatol.
  • 2020 Jan;58(1):55-58.
Extramammary Paget’s disease (EMPD) is a rare malignant neoplasm of the apocrine sweat gland-bearing skin in the genital, perianal, or axillary region. EMPD may simultaneously occur in the genital and...
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Clinical Features and Association with Visceral Malignancy in 80 Patients with Sebaceous Neoplasms

Kim JE, Kim JH, Chung KY, Yoon JS, Roh MR

BACKGROUND: Sebaceous neoplasm is a rare subgroup of appendageal tumors that differentiate towards sebaceous adnexal structures of the skin and are known to be associated with visceral malignancy. OBJECTIVE: We aimed...
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Immediate Umbilical Reconstruction after a Mohs Micrographic Surgery for Primary Cutaneous Adenoid Cystic Carcinoma Arising in the Umbilicus

Kim JE, Roh MR, Chung KY

Adenoid cystic carcinoma (ACC) is a malignant neoplasm of glands commonly occurs in salivary glands. Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare form of ACC that primarily presents...
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Role of Helix 8 in Dopamine Receptor Signaling

Yang HS, Sun N, Zhao X, Kim HR, Park HJ, Kim KM, Chung KY

G protein-coupled receptors (GPCRs) are membrane receptors whose agonist-induced dynamic conformational changes trigger heterotrimeric G protein activation, followed by GRK-mediated phosphorylation and arrestin-mediated desensitization. Cytosolic regions of GPCRs have been...
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