Tuberc Respir Dis.  1986 Dec;33(4):196-201. 10.4046/trd.1986.33.4.196.

Natural Killer Cell Mediated Cytotoxicity and Antibody-Dependent Cell Mediated Cytotoxicity in Tuberculosis Patients (1)

• KMID: 2528680
• DOI: http://doi.org/10.4046/trd.1986.33.4.196

Abstract

Cellular immunity is predominantly involved in pulmonary tuberculosis. Natural Killer (NK) cells and Killer (K) cells play an important role in cellular immunity. Natural Killer cell mediated cytotoxicity (NKMC) was studied in 51 patients with active tuberculosis and 39 healthy controls. Antibody-dependent cell mediated cytotoxicity(ADCC) was studied in 41 patients with active tuberculosis and 15 healthy controls There were no differences between the patients and the controls in NKMC and ADCC. There were no significant differences in the mean values of NKMC and ADCC among the minimal, moderately advanced and far advanced pulmonary tuberculosis patients. We conclude that NK and K cells are not of prime importance in the body’s defence against tuberculosis