Clin Pediatr Hematol Oncol.  2018 Oct;25(2):170-174. 10.15264/cpho.2018.25.2.170.

Cytomegalovirus-Associated Severe Direct Antiglobulin Test Negative Hemolytic Anemia: A Case Report

Affiliations
  • 1Department of Pediatrics, College of Medicine, Gyeongsang National University, Korea. pedneu@gnu.ac.kr
  • 2Gyeongsang Institute of Health Science, Jinju, Korea.

Abstract

Cytomegalovirus is a common virus that is mostly asymptomatic when infected, but rarely causes life-threatening hemolysis especially in immunocompromised children. We report a case of antiglobulin test negative severe hemolytic anemia caused by cytomegalovirus infection developed in an immune competent 9-year-old girl. The patient's hemoglobin level was 4.8 g/dL on the day of admission. The diagnosis was achieved by exclusion of other causes of hemolytic anemia and serological evidence of recent CMV infection. The patient was successfully treated with anti-viral agents and steroids resulting in recovery from anemia. Clinicians should consider cytomegalovirus infection in the differential diagnosis of hemolytic anemia in pediatric patients.

Keyword

Hemolytic anemia; Cytomegalovirus

MeSH Terms

Anemia
Anemia, Hemolytic*
Child
Coombs Test*
Cytomegalovirus
Cytomegalovirus Infections
Diagnosis
Diagnosis, Differential
Female
Hemolysis
Humans
Steroids
Steroids
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