Clin Pediatr Hematol Oncol.
2018 Oct;25(2):170-174. 10.15264/cpho.2018.25.2.170.
Cytomegalovirus-Associated Severe Direct Antiglobulin Test Negative Hemolytic Anemia: A Case Report
- Affiliations
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- 1Department of Pediatrics, College of Medicine, Gyeongsang National University, Korea. pedneu@gnu.ac.kr
- 2Gyeongsang Institute of Health Science, Jinju, Korea.
- KMID: 2435410
- DOI: http://doi.org/10.15264/cpho.2018.25.2.170
Abstract
- Cytomegalovirus is a common virus that is mostly asymptomatic when infected, but rarely causes life-threatening hemolysis especially in immunocompromised children. We report a case of antiglobulin test negative severe hemolytic anemia caused by cytomegalovirus infection developed in an immune competent 9-year-old girl. The patient's hemoglobin level was 4.8 g/dL on the day of admission. The diagnosis was achieved by exclusion of other causes of hemolytic anemia and serological evidence of recent CMV infection. The patient was successfully treated with anti-viral agents and steroids resulting in recovery from anemia. Clinicians should consider cytomegalovirus infection in the differential diagnosis of hemolytic anemia in pediatric patients.
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