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Performance Evaluation of Infusion Systems for Red Blood Cell Transfusion

Kim MS, Kim JS, Lim E, Park H, Hwang SH, Oh HB, Ko DH

BACKGROUND: Transfusion in neonates and infants can be performed using an electromechanical infusion system that has appropriate accuracy in terms of flow rate, volume, and bolus. However, there are no...
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Novel Isoquinolinamine and Isoindoloquinazolinone Compounds Exhibit Antiproliferative Activity in Acute Lymphoblastic Leukemia Cells

Roolf C, Saleweski , Stein A, Richter A, Maletzki C, Sekora A, Escobar HM, Wu XF, Beller M, Junghanss

Nitrogen-containing heterocycles such as quinoline, quinazolinones and indole are scaffolds of natural products and have broad biological effects. During the last years those structures have been intensively synthesized and modified...
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Rifampin-Induced Immune Hemolytic Anemia during Treatment of Pulmonary Tuberculosis in a Patient with Primary Sjogren's Syndrome

Souk JW, Kim YK, Jang GE, Jeong HS, Uh ST, Kim KU, Koo SM, Lee BY, Noh H, Shin WY, Shin JW, Jin SY

Drug-induced immune hemolytic anemia is a rare disease that occurs in 1 in 1 million individuals of the general population. Rifampin-induced immune hemolytic anemia is caused by drug-dependent antibodies and...
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Characteristic profiles of biofilm, enterotoxins and virulence of Staphylococcus aureus isolates from dairy cows in Xinjiang Province, China

Wu Y, Li J, Qiao M, Meng D, Meng Q, Qiao J, Zhang X, Wang L, Cai K, Zhang J, Zhang Z, Yu W, Cai X

As an important zoonotic pathogen, Staphylococcus aureus has led to serious mastitis and endometritis in infected dairy cows. In this study, a total of 164 strains of S. aureus were...
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Evaluation of Point-of-Care Testing for C-Reactive Protein in Forensic Medicine

Na JY, Park JT

BACKGROUND: C-reactive protein (CRP) is an acute-phase protein whose level increases in response to tissue injury, infection, or other inflammation. It is used in clinical and forensic settings. Point-of-care (POC)...
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Effects of irradiation and leukoreduction on down-regulation of CXCL-8 and storage lesion in stored canine whole blood

Yang H, Kim W, Bae J, Kim H, Kim S, Choi J, Park J, Jung DI, Koh H, Yu D

White blood cells (WBCs) and storage period are the main factors of transfusion reactions. In the present study, cytokine/chemokine concentrations after leukoreduction (LR) and irradiation (IR) in stored canine whole...
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Prevalence of O-serogroups, virulence genes, and F18 antigenic variants in Escherichia coli isolated from weaned piglets with diarrhea in Korea during 2008–2016

Do KH, Byun JW, Lee WK

To diagnose colibacillosis, detection of O-serogroups and virulence genes has been recommended worldwide. The prevalence of virulence factors can fluctuate over time. The objectives of this study were to determine...
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Promyelocytic Leukemoid Reaction: Unusual Findings in a Patient with Sepsis

Kim YK

Neutrophilic leukemoid reaction may occur in many situations, including hemolysis, malignancy, infection, and exposure to certain toxins. It usually shows morphological overlap with chronic myeloid leukemia in which promyelocytes are...
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Early Experiences Using Cocoon Occluders for Closure of a Ventricular Septal Defect

Park H, Song J, Kim ES, Huh J, Kang IS

BACKGROUND: Transcatheter device closure of ventricular septal defect (VSD) has become an attractive alternative to surgery. We report here on our early experiences of transcatheter closure of VSD using Cocoon...
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Delayed Postpartum Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome Successfully Treated with Dexamethasone

Kim TH, Kim N, Park JY, Oh KJ, Hong JS

The treatment of choice for preeclampsia is delivery. However, delivery is not always the end of preeclampsia. We present a case of preeclampsia complicated by postpartum hemolysis, elevated liver enzymes,...
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Laboratory Workup of Drug-Induced Immune Hemolytic Anemia

Nah H, Kim HO

Drug-induced immune hemolytic anemia (DIIHA) is rare condition that is often very difficult to diagnose. For proper diagnosis of DIIHA, careful interpretation of laboratory findings as well as correlation between...
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Cryohemolysis, erythrocyte osmotic fragility, and supplementary hematimetric indices in the diagnosis of hereditary spherocytosis

Emilse LA, Cecilia H, María TM, Eugenia MM, Alicia IB, Lazarte SS

BACKGROUND: Hereditary spherocytosis (HS) is a chronic hemolytic anemia characterized by microspherocytes in the peripheral blood and increased erythrocyte osmotic fragility (EOF). This study evaluated the cryohemolysis test (CHT); initial...
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Rhabdomyolysis and diabetic ketoacidosis after bee sting: A case report

Shin SH, Bae SH, Jung HJ, Lee SA, Kim SW, Chang HH, Park HK, Lee JM, Kim S

Bee stings result in diverse clinical manifestations from localized pain, rash to life-threatening systemic allergic reactions or toxic reactions. Toxic reactions include skin necrosis, pancreatitis, acute renal failure, hemolysis or...
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Anesthetic and Perioperative Management of Patient with Paroxysmal Nocturnal Hemoglobinuria

Choi EK, Kim KB, Park SJ, Park KB

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder. Surgery, anesthesia, infection, trauma, and pregnancy can exacerbate hemolysis and thrombotic risk by increasing complement activity. However, perioperative...
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An anesthetic experience in severe preeclampsia patient suspected HELLP syndrome with an intraperitoneal hemorrhage caused by a rapidly progressed liver rupture: A case report

Heo HJ, Kim H, Lee JH, Im SM, Kim OH, Lee HG

The diagnosis of HELLP syndrome associated with preeclampsia-eclampsia during pregnancy uses three test results, including hemolysis, elevated liver enzyme, low platelets and their related clinical symptoms. Liver rupture is a...
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Cytomegalovirus-Associated Severe Direct Antiglobulin Test Negative Hemolytic Anemia: A Case Report

Hong HJ, Cho YH, Lim JY, Yeom JS, Park JS, Park ES, Seo JH, Woo HO, Youn HS

Cytomegalovirus is a common virus that is mostly asymptomatic when infected, but rarely causes life-threatening hemolysis especially in immunocompromised children. We report a case of antiglobulin test negative severe hemolytic...
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Relationships between Virulence Factors and Antimicrobial Resistance among Escherichia coli Isolated from Urinary Tract Infections and Commensal Isolates in Tehran, Iran

Karam MR, Habibi M, Bouzari S

OBJECTIVES: Uropathogenic Escherichia coli (UPEC) are the major cause of urinary tract infections (UTIs). Here, we determined whether sensitivity to antibiotics was related to the prevalence of iron scavenging genes,...
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Treatment of renal anemia: Erythropoiesis stimulating agents and beyond

Biggar P, Kim GH

Anemia, complicating the course of chronic kidney disease, is a significant parameter, whether interpreted as subjective impairment or an objective prognostic marker. Renal anemia is predominantly due to relative erythropoietin...
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Algorithm for Differential Diagnosis of in Vitro and in Vivo Hemolysis in Anticoagulated Blood Specimens

Lee JH, Kim Y, Yoo G, Kim J, Yoon KJ, Uh Y

BACKGROUND: Hemolytic specimens contain components that interfere with clinical laboratory results. We evaluated previously published hemolysis indices (HI) and developed an algorithm for differentiating between mechanical hemolysis and immune-mediated hemolysis...
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Efficacy of eculizumab in paroxysmal nocturnal hemoglobinuria patients with or without aplastic anemia: prospective study of a Korean PNH cohort

Choi CW, Jang JH, Kim JS, Jo DY, Lee JH, Kim SH, Kim YK, Won JH, Chung JS, Kim H, Lee JH, Kim MK, Eom HS, Hyun SY, Kim JA, Lee JW

BACKGROUND: Patients with paroxysmal nocturnal hemoglobinuria (PNH) often have concurrent aplastic anemia (AA). This study aimed to determine whether eculizumab-treated patients show clinical benefit regardless of concurrent AA. METHODS: We analyzed...
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