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Red Blood Cell Autoantibodies in Patients Treated with Immune Checkpoint Inhibitors

Yoon E, Kim TY, Mun SK, Cho D

Immune-related adverse events, including immune hemolytic anemia, have been reported in patients treated with immune checkpoint inhibitors. In particular, RBC autoantibodies are important because they can cause hemolytic anemia and...
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A clinical case of bovine anemia due to Theileria orientalis group in a non-grazed dairy cow in the upper part of South Korea

Espiritu HM, Lee HW, Lee SS, Cho YI

This study reports the detection and genotyping of the first clinical case of bovine anemia due to Theileria orientalis group (BATOG) in non-grazed dairy cow in upper Korea. Blood and...
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Epidemiological Study of Hereditary Hemolytic Anemia in the Korean Pediatric Population during 1997–2016: a Nationwide Retrospective Cohort Study

Shim YJ, Jung HL, Shin HY, Kang HJ, Choi JY, Hah JO, Lee JM, Lim YT, Yang EJ, Baek HJ, Choi HS, Yoo KH, Park JE, Kim S, Kim JY, Park ES, Im HJ, Chueh HW, Kim SK, Lee JH, Yoo ES, Park HJ, Lee JA, Park M, Kang HS, Park JK, Lee NH, Park SK, Lee YH, Lee SW, Choi EJ, Kong SG

Background: Hereditary hemolytic anemia (HHA) is a rare disease characterized by premature red blood cell (RBC) destruction due to intrinsic RBC defects. The RBC Disorder Working Party of the Korean...
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Successful Treatment of a Korean Infant with Giant Cell Hepatitis with Autoimmune Hemolytic Anemia Using Rituximab

Kim YH, Kim JW, Lee EJ, Kang GH, Kang HJ, Moon JS, Ko JS

Giant cell hepatitis with autoimmune hemolytic anemia (AHA) is a rare disease of infancy characterized by the presence of both Coombs-positive hemolytic anemia and progressive liver disease with giant cell...
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The First Korean Family with Hemoglobin-M Milwaukee-2 Leading to Hereditary Methemoglobinemia

Kim DS, Baek HJ, Kim BR, Yoon BA, Lee JH, Kook H

Hemoglobin M (HbM) is a group of abnormal hemoglobin variants that form methemoglobin, which leads to cyanosis and hemolytic anemia. HbM-Milwaukee-2 is a rare variant caused by the point mutation...
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Clinical Case of a Transfusion-Associated Canine Mycoplasma haemocanis Infection in the Republic of Korea: A Case Report

Kim J, Lee D, Yoon E, Bae H, Chun D, Kang JG, Jung DI, Yu DH

This report describes the first clinical case of a transfusion-associated Mycoplasma haemocanis infection in a dog in Korea. A 6-year-old male Maltese underwent a red blood cell transfusion for idiopathic...
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Treatment of autoimmune hemolytic anemia: real world data from a reference center in Mexico

Jaime-Pérez JC, Aguilar-Calderón P, Salazar-Cavazos L, Gómez-De León A, Gómez-Almaguer D

BACKGROUND: Warm autoimmune hemolytic anemia (w-AIHA) is an uncommon disease with heterogeneous response to treatment. Steroids are the standard treatment at diagnosis, whereas rituximab has recently been recommended as the...
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Efficacy of L-carnitine on ribavirin-induced hemolytic anemia in patients with hepatitis C virus infection

Sato S, Moriya K, Furukawa M, Saikawa S, Namisaki T, Kitade M, Kawaratani H, Kaji K, Takaya H, Shimozato , Sawada Y, Seki K, Kitagawa K, Akahane T, Mitoro A, Okura Y, Yamao J, Yoshiji H

BACKGROUND/AIMS: L-carnitine not only alleviates hyperammonemia and reduces muscle cramps in patients with liver cirrhosis, but also improves anemia in patients with chronic hepatitis and renal dysfunction. This study prospectively...
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Rifampin-Induced Immune Hemolytic Anemia during Treatment of Pulmonary Tuberculosis in a Patient with Primary Sjogren's Syndrome

Souk JW, Kim YK, Jang GE, Jeong HS, Uh ST, Kim KU, Koo SM, Lee BY, Noh H, Shin WY, Shin JW, Jin SY

Drug-induced immune hemolytic anemia is a rare disease that occurs in 1 in 1 million individuals of the general population. Rifampin-induced immune hemolytic anemia is caused by drug-dependent antibodies and...
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Anesthetic Experience of Cesarean Section in Evans Syndrome

Cho A

Evans syndrome is an uncommon condition defined by the combination of immune thrombocytopenia and autoimmune hemolytic anemia in the absence of known underlying cause. Association of Evans syndrome with pregnancy...
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Laboratory Workup of Drug-Induced Immune Hemolytic Anemia

Nah H, Kim HO

Drug-induced immune hemolytic anemia (DIIHA) is rare condition that is often very difficult to diagnose. For proper diagnosis of DIIHA, careful interpretation of laboratory findings as well as correlation between...
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Splenic myeloid metaplasia in warm autoimmune hemolytic anemia (wAIHA): a retrospective study

Anguiano-Álvarez VM, Hernández-Company A, Hamdan-Pérez N, Montante-M D, Zúñiga-Tamayo DA, Rodríguez-Rodríguez S, Pomerantz , Tuna-Aguilar EJ

BACKGROUND: Splenic myeloid metaplasia (SMM) is a kind of extramedullary hematopoiesis, whereas its clinical significance in wAIHA remains unclear. The aim of this study is evaluating the frequency and clinical...
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CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice

Kim JI, Park JS, Kwak J, Lim HJ, Ryu SK, Kwon E, Han KM, Nam KT, Lee HW, Kang BC

CD47 (integrin-associated protein), a multi-spanning transmembrane protein expressed in all cells including red blood cells (RBCs) and leukocytes, interacts with signal regulatory protein α (SIRPα) on macrophages and thereby inhibits...
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Quetiapine Induced Autoimmune Hemolytic Anemia in a Child Patient: A Case Report

Arici A, Altun H, Acipayam C

Autoimmune hemolytic anemia is a disease characterized with destruction of erythrocytes as a result of antibody produce against patient's own erythrocytes and anemia. Autoimmune hemolytic anemia can be roughly stratified...
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Cytomegalovirus-Associated Severe Direct Antiglobulin Test Negative Hemolytic Anemia: A Case Report

Hong HJ, Cho YH, Lim JY, Yeom JS, Park JS, Park ES, Seo JH, Woo HO, Youn HS

Cytomegalovirus is a common virus that is mostly asymptomatic when infected, but rarely causes life-threatening hemolysis especially in immunocompromised children. We report a case of antiglobulin test negative severe hemolytic...
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Treatment and response of autoimmune cytopenia occurring after allogeneic hematopoietic cell transplantation in children

Hwang-Bo S, Kim SK, Lee JW, Jang PS, Chung NG, Jeong DC, Cho B, Kim HK

BACKGROUND: Autoimmune cytopenia (AIC) is a rare complication of allogeneic hematopoietic cell transplantation (HCT). In this study, we reviewed the diagnosis, treatment and response to therapy for pediatric patients with...
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Diagnostic approaches for inherited hemolytic anemia in the genetic era

Kim Y, Park J, Kim M

Inherited hemolytic anemias (IHAs) are genetic diseases that present with anemia due to the increased destruction of circulating abnormal RBCs. The RBC abnormalities are classified into the three major disorders...
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Ceftizoxime-induced immune hemolytic anemia associated with multi-organ failure

Huh JY, Ahn A, Kim H, Kwon SW, An S, Lee JY, Kwon BS, Oh EH, Park DH, Huh JW

Drug-induced immune hemolytic anemia (DIIHA) is a rare side effect of drugs. DIIHA may cause a systemic inflammatory response that results in acute multi-organ failure and death. Ceftizoxime belongs to...
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Candida albicans urinary tract infection in a Shih Tzu dog with immune-mediated hemolytic anemia

Jang IS, Yoon WK, Hyun C

An 8-year-old castrated male Shih Tzu dog (weighing 7.0 kg) presented with anemia and lethargy. Initial diagnosis indicated immune-mediated hemolytic anemia. During therapy, a secondary urinary infection, probably due to...
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Warm autoimmune hemolytic anemia: experience from a single referral center in Mexico City

Alonso HC, Manuel AA, Amir CG, Sergio RR, Allan P, Xavier LK, Juventina

BACKGROUND: Autoimmune hemolytic anemia (AIHA) is characterized by an autoimmune-mediated destruction of red blood cells. Warm AIHA (wAIHA) represents 60% of AIHA cases and is associated with the positive detection...
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