Korean J Blood Transfus.  1995 Dec;6(2):177-184.

Cryopathic Hemolytic Anemia: A case report

Abstract

The cryopathic hemolytic anemia is an autoimmune hemolytic anemia induced by cold antibody. Authors report a case of cryopathic hemolytic anemia confirmed by immunohematologic examination. A 22-year-old man was admitted at Kyung Hee Medical Center in March, 1994, with a past history of Kleinerfelter's syndrome and complained jaundice as well as dizziness. Direct antiglobulin test using polyvalent and anti-C3d monovalent antisera was positive, but was negative against anti-IgG, anti-IgA, and anti-IgM monovalent antisera. Cold agglutinin titer was as high as 1:1024 at 4 degrees C and anti-I specificity was confirmed by using cord bloods. The patient was not improved despite transfusion of washed red cells and administration of prednisolone, and on 16th day of hospitalization he manifested sudden episode of headache and loss of conscioussness, soon followed by death.


MeSH Terms

Anemia, Hemolytic*
Anemia, Hemolytic, Autoimmune
Coombs Test
Dizziness
Fetal Blood
Headache
Hospitalization
Humans
Immune Sera
Jaundice
Prednisolone
Sensitivity and Specificity
Young Adult
Immune Sera
Prednisolone
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