Korean J Intern Med.
2012 Dec;27(4):463-466.
Sudden Atelectasis and Respiratory Failure in a Neutropenic Patient: Atypical Presentation of Pseudomembranous Necrotizing Bronchial Aspergillosis
- Affiliations
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- 1Department of Internal Medicine, Korea University Medical Center, Seoul, Korea.
- 2Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kstwoh@skku.edu
- 3Department of Radiology, Korea University Medical Center, Seoul, Korea.
- 4Department of Laboratory Medicine, Korea University Medical Center, Seoul, Korea.
- 5Department of Pathology, Korea University Medical Center, Seoul, Korea.
Abstract
- Pseudomembranous necrotizing bronchial aspergillosis (PNBA) is a rare form of invasive aspergillosis with a very poor prognosis. The symptoms are non-specific, and the necrotizing plugs cause airway obstruction. Atelectasis and respiratory failure can be the initial manifestations. Recently, we treated an immunocompromised patient with PNBA, who presented with a sudden onset of atelectasis and acute respiratory failure. There were no preceding signs except for a mild cough and one febrile episode. Bronchoscopy revealed PNBA, and Aspergillus nidulans was cultured from the bronchial wash.
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