Tuberc Respir Dis.  2007 Sep;63(3):278-282. 10.4046/trd.2007.63.3.278.

A Case of Pseudomembranous Necrotizing Bronchial Aspergillosis in An Old Age Host

• Lee SE
• Jun EJ
• Song JH
• Shin JW
• Kim JY
• Park IW
• Choi BW
• Choi JC
• Kim MK

• KMID: 1518420
• DOI: http://doi.org/10.4046/trd.2007.63.3.278

Abstract

Invasive aspergillus tracheobronchitis is uncommon manifestation of infection due to Aspergillus species, occurring in severely immunocompromised patients who are generally neutropenic with haematological diseases, AIDS, or after heart and lung transplantation. The pseudomembranous form is the most severe condition and is usually fatal despite treatment with antifungal agents. However, there are a few cases reported with no apparent severe compromise in the host defences. We encountered a pseudomembranous necrotizing bronchial aspergillosis in a 73-year old male patient, who was treated successfully with antifungal agents.

Keyword

Aspergillosis; Pseudomembranous; Tracheobronchitis

MeSH Terms

Aged
Antifungal Agents
Aspergillosis*
Aspergillus
Heart
Humans
Immunocompromised Host
Lung Transplantation
Male
Antifungal Agents

Figure

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  Figure 1 A chest radiograph on admission demonstrates pneumonic infiltration in left upper lung field and right lower lung field.

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  Figure 2 Chest CT scan demonstrates peribronchial necrotizing consolidations with centrilobular nodules (A), and diffuse bronchial wall thickening (B).

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  Figure 3 Brochoscopic picture demonstrates extensive whitish exudative membranes covering the left upper lobe bronchus(A) and upper division (B).

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  Figure 4 The bronchoscopic biopsy shows numerous branching hyphae with septation.(H&E, ×400)

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  Figure 5 Follow up brochoscopic view of left upper lobe bronchus showing improved Inflammation with minimal whitish exudative membranes: (A) left main bronchus; (B) left upper lobe bronchus.

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