Blood Res.  2018 Dec;53(4):269-275. 10.5045/br.2018.53.4.269.

Comparison of mean platelet volume levels in coronary artery ectasia and healthy people: systematic review and meta-analysis

Affiliations
  • 1Clinical Research Development Center, Imam Ali and Taleghani Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran. afsharshahmohammadi@yahoo.com

Abstract

Coronary artery ectasia (CAE) is defined as the dilation of a segment of a coronary vessel to at least 1.5 times the diameter of its normal adjacent segment. Mean platelet volume (MPV) plays a role in acute coronary syndromes, with high MPV correlating to poor prognosis for acute thrombotic events and CAE. Several studies investigated the relationship between MPV and CAE, resulting in conflicting results. These results led us to systematically review all studies investigating the relationship between MPV and ectatic heart diseases by performing a meta-analysis study in order to report a unified result. This meta-analysis study investigated all case-control articles examining the relationship between MPV and CAE. All studies in the following databases published until January 31, 2018, were investigated: Science Direct, Scopus, PubMed, Google Scholar, and Web of Science. Following a quality control evaluation, 14 articles, all of which were published following studies performed in Turkey from 2007 to 2016, met the criteria for study inclusion. After pooling the results from all of the articles, a total standardized mean difference (SMD) value of 0.584 (95% CI, 0.219, 0.95) was obtained using the D+L pooled SMD, indicating a significant difference (P=0.002) between the two groups, with higher MPV values in ectatic patients when comparing to healthy individuals. Therefore, increased MPV levels were significantly related to CAE, suggesting that platelets, with their inflammatory and thrombotic activities, play a role in this disease. Therefore, anti-platelet and anti-inflammatory therapies may be effective in treating CAE.

Keyword

Coronary artery ectasia; Mean platelet volume; Meta-analysis

MeSH Terms

Acute Coronary Syndrome
Case-Control Studies
Coronary Vessels*
Dilatation, Pathologic*
Heart Diseases
Humans
Mean Platelet Volume*
Prognosis
Quality Control
Turkey

Figure

  • Fig. 1 Flow chart of study selection process.

  • Fig. 2 Forest plot of the association between MPV and CAE.a)Weights are from random effects analysis.

  • Fig. 3 Publication bias estimated by the Begg's test.

  • Fig. 4 Publication bias estimated by the Egger's test.


Reference

1. Beresniak A, Caruba T, Sabatier B, Juillière Y, Dubourg O, Danchin N. Cost-effectiveness modelling of percutaneous coronary interventions in stable coronary artery disease. World J Cardiol. 2015; 7:594–602. PMID: 26516413.
Article
2. Widmer RJ, Flammer AJ, Lerman LO, Lerman A. The Mediterranean diet, its components, and cardiovascular disease. Am J Med. 2015; 128:229–238. PMID: 25447615.
Article
3. Yu L, Gu T, Shi E, Xiu Z, Fang Q, Liu B. Surgical repair of coronary artery fistula combined with coronary artery ectasia in adults. J Card Surg. 2013; 28:222–227. PMID: 23675679.
Article
4. Zipes D, Libby P, Bonow RO, Mann DL, Tomaselli GF. Braunwald's heart disease: a textbook of cardiovascular medicine. 11th ed. Philadelphia, PA: Elsevier;2018. p. 63.
5. Wang Y, Wang Y, Yin D, Dou K, Wu Y, Song W. The beneficial effects of renin-angiotensin system blockades on 2 year outcomes in coronary artery ectasia patients. Curr Med Res Opin. 2017; 33:1677–1684. PMID: 28598221.
Article
6. Arif Yalcin A, Faruk Akturk I, Celik O, et al. Coronary artery ectasia is associated with the c.894G>T (Glu298Asp) polymorphism of the endothelial nitric oxide synthase gene. Tohoku J Exp Med. 2014; 232:137–144. PMID: 24573064.
7. Fariba F, Moradi M, Arabi A, Ghaderi B. Prevalence of coronary artery ectasia with atherosclerosis and associated risk factors in the West of Iran: a cross-sectional study. J Res Health Sci. 2016; 16:22–25. PMID: 27061992.
8. Boles U, Johansson A, Wiklund U, et al. Cytokine disturbances in coronary artery ectasia do not support atherosclerosis pathogenesis. Int J Mol Sci. 2018; 19:E260. PMID: 29337902.
Article
9. Sansanayudh N, Anothaisintawee T, Muntham D, McEvoy M, Attia J, Thakkinstian A. Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol. 2014; 175:433–440. PMID: 25017904.
Article
10. Sharma V, Aggarwal A. Helicobacter pylori: Does it add to risk of coronary artery disease. World J Cardiol. 2015; 7:19–25. PMID: 25632315.
Article
11. Hamur H, Kalkan K, Duman H, et al. Plateletcrit and platelet distribution width as independent predictors of coronary artery ectasia. Koşuyolu Heart J. 2016; 19:173–178.
Article
12. Sarli B, Baktır AO, Saglam H, et al. No relevant association between coronary artery ectasia and mean platelet volume, gamma-glutamyltransferase and uric acid levels. Turk Kardiyol Dern Ars. 2013; 41:598–603. PMID: 24164990.
13. Soydinc S, Turkbeyler IH, Pehlivan Y, et al. Mean platelet volume seems to be a valuable marker in patients with systemic sclerosis. Inflammation. 2014; 37:100–106. PMID: 23996103.
Article
14. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011; 17:47–58. PMID: 21247392.
15. Ozbek K, Katlandur H, Keser A, Ulucan S, Ozdil H, Ulgen MS. Is there a relationship between mean platelet volume and the severity of coronary ectasia? Biomed Res. 2016; 27:816–820.
16. Keser A, Ozbek K, Ulucan S, Katlandur H, Bilgi M, Ozdil H. Relationship between red cell distribution width levels and severity of coronary artery ectasia. Eur Rev Med Pharmacol Sci. 2016; 20:1571–1574. PMID: 27160130.
17. Ayhan SS, Ozturk S, Erdem A, et al. Relation of neutrophil/lymphocyte ratio with the presence and severity of coronary artery ectasia. Turk Kardiyol Dern Ars. 2013; 41:185–190. PMID: 23703551.
18. Varol E, Akcay S, Ozaydin M, Erdogan D, Dogan A. Mean platelet volume in patients with coronary artery ectasia. Blood Coagul Fibrinolysis. 2009; 20:321–324. PMID: 19417633.
Article
19. Demir M, Keceoglu S, Melek M. The relationship between blood monocyte count and coronary artery ectasia. Cardiol Res. 2013; 4:159–164. PMID: 28352439.
Article
20. Demir M, Demir C, Keceoglu S. The relationship between blood monocyte count and ccoronary artery ectasia. Cardiol Res. 2014; 5:151–154. PMID: 28348713.
21. Sen N, Tavil Y, Yazici HU, et al. Mean platelet volume in patients with coronary artery ectasia. Med Sci Monit. 2007; 13:CR356–CR359. PMID: 17660725.
22. Demir S, Avsar MK, Karakaya Z, et al. Increased mean platelet volume is associated with coronary artery ectasia. Postępy Kardiol Interwencyjnej. 2013; 9:241–245. PMID: 24570725.
Article
23. Balta S, Demirkol S, Celik T, et al. Association between coronary artery ectasia and neutrophil-lymphocyte ratio. Angiology. 2013; 64:627–632. PMID: 23471489.
Article
24. Isik T, Kurt M, Ayhan E, et al. Relation of red cell distribution width with presence and severity of coronary artery ectasia. Clin Appl Thromb Hemost. 2012; 18:441–447. PMID: 22619398.
Article
25. Bitigen A, Tanalp AC, Elonu OH, Karavelioglu Y, Ozdemir N. Mean platelet volume in patients with isolated coronary artery ectasia. J Thromb Thrombolysis. 2007; 24:99–103. PMID: 17243013.
Article
26. Can Y, Harun K, Kocayigit I, et al. Association between coronary artery ectasia and platelet to lymphocyte ratio. Am J Cardiol. 2016; 117(Suppl 1):S46.
27. Erdem E, Erdem D, Dilek M, et al. Red cell distribution width and mean platelet volume in amyloidosis. Clin Appl Thromb Hemost. 2014; 20:334–337. PMID: 23076775.
Article
28. Beyan C, Beyan E. Mean platelet volume may not be changed in patients with coronary artery ectasia. Erciyes Med J. 2015; 37:85–86.
Article
29. Yilmaz F, Koklu E, Kizilirmak Yilmaz F, Sarionder Gencer E, Alparslan AS, Yildırimturk O. Evaluation of mean platelet volume and platelet distribution width in patients with asymptomatic intermediate carotid artery plaque. Kardiol Pol. 2017; 75:35–41. PMID: 27714714.
Article
Full Text Links
  • BR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr