Korean J Intern Med.  2016 Nov;31(6):1009-1017. 10.3904/kjim.2016.078.

Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease

• Choi DH
• Kang SH
• Song H

• KMID: 2382850
• DOI: http://doi.org/10.3904/kjim.2016.078

Abstract

Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombosis. They secrete and express many substances that are crucial mediators of coagulation, inflammation, and atherosclerosis. Mean platelet volume (MPV) is a precise measure of platelet size, and is routinely reported during complete blood count analysis. Emerging evidence supports the use of MPV as a biomarker predicting the risk of ischemic stroke in patients with atrial fibrillation, and as a guide for prescription of anticoagulation and rhythm-control therapy. In addition, MPV may predict the clinical outcome of percutaneous coronary intervention (PCI) in patients with coronary artery disease and indicate whether additional adjunctive therapy is needed to improve clinical outcomes. This review focuses on the current evidence that MPV may be a biomarker of the risk and prognosis of common heart diseases, particularly atrial fibrillation and coronary artery disease treated via PCI.

Keyword

Mean platelet volume; Atrial fibrillation; Ischemic stroke; Coronary artery disease; Percutaneous coronary intervention

MeSH Terms

Atherosclerosis
Atrial Fibrillation
Blood Cell Count
Blood Platelets
Coronary Artery Disease
Heart Diseases*
Heart*
Humans
Inflammation
Mean Platelet Volume*
Percutaneous Coronary Intervention
Prescriptions
Prognosis*
Stroke
Thrombosis