Ann Dermatol.  2018 Dec;30(6):708-711. 10.5021/ad.2018.30.6.708.

Concurrence of Circumscribed Morphea and Segmental Vitiligo: A Case Report

• Lee JS
• Park HS
• Cho S
• Yoon HS

• KMID: 2428928
• DOI: http://doi.org/10.5021/ad.2018.30.6.708

Abstract

Although a few reports have noted the concurrent presentation of morphea and vitiligo at distinctly separate sites in the same patient, it is extremely rare that these two conditions occur at the same sites in a patient. We report the case of a 10-year-old Korean girl with morphea and vitiligo and those lesions occurred at the same sites and progressed simultaneously. An autoimmunity and a cutaneous mosaicism was considered to be involved in such an unique presentation as the pathogenesis is concerned.

Keyword

Autoimmunity; Localized scleroderma; Morphea; Mosaicism; Vitiligo

MeSH Terms

Autoimmunity
Child
Female
Humans
Mosaicism
Scleroderma, Localized*
Vitiligo*

Figure

• 

  Fig. 1 (A) Multiple hypopigmented patches with small satellite lesions on the left upper arm, distributed along the T1 dermatome. (B) Indurated, atrophic, shiny areas at the center of hypopigmented patches.

• 

  Fig. 2 (A) Biopsy from the depigmented lesion (H&E, ×100). Degenerated thickned dermal collagen bundles with focal dense lymphocytic infiltration. (B and C) Biopsy from the depigmented lesion (H&E, ×400) (B) showed a decresed basal pigmentation compared to adjacent normal peripheray (H&E, ×400) (C). Mild superficial perivascular lymphocytic infiltration was observed in the normal periphery (C). (D and E) Biopsy from the depigmented lesion (Melan-A/MART-1, ×200) (D) showed decreased Melan A positive melanocytes compared to adjacent normal periphery (Melan-A/MART-1, ×200) (E). (F and G) Biopsy from the depigmented lesion (S-100, ×200) (F) showed decreased S-100 positive melanocytes compared to adjacent normal periphery (S-100, ×200) (G).

• 

  Fig. 3 (A) Lesions before the treatment. (B) Lesions after 6 months of treatment. Improvement with repigmentation.

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