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Autoimmune Gastritis Accompanied by a Schwannoma Presenting as a Subepithelial Tumor

Ahn YH, Hwang KB, Seo GS

Autoimmune gastritis (AIG), a chronic inflammatory disease occurs as a result of a complex interaction between host-related and environmental factors. AIG may progress to severe atrophic gastritis secondary autoimmune-mediated parietal...
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Immunopathogenesis of childhood idiopathic nephrotic syndrome

Cheong HI

Pediatric nephrotic syndrome (NS) is a clinical syndrome characterized by massive proteinuria, hypoalbuminemia, and generalized edema. Most childhood NS cases are idiopathic (with an unknown etiology). Traditional therapeutic approaches based...
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Phosphatase Ssu72 Is Essential for Homeostatic Balance Between CD4+ T Cell Lineages

Kim MH, Lee CW

Ssu72, a dual-specificity protein phosphatase, not only participates in transcription biogenesis, but also affects pathophysiological functions in a tissue-specific manner. Recently, it has been shown that Ssu72 is required for...
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Engineering Cell Therapies for Autoimmune Diseases: From Preclinical to Clinical Proof of Concept

Oh S, Payne AS

Autoimmune diseases are caused by a dysfunction of the acquired immune system. In a subset of autoimmune diseases, B cells escaping immune tolerance present autoantigen and produce cytokines and/or autoantibodies,...
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Predictors of associated and multiple autoimmunity in children and adolescents with type 1 diabetes mellitus

Kakleas K, Kossyva L, Korona A, Kafassi N, Karanasios S, Karavanaki K

Purpose: Type 1 diabetes mellitus (T1DM) is an autoimmune condition characterised by the presence of antipancreatic antibodies. The autoimmune process is also directed against other organs, most frequently against the...
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Demographic and diagnostic markers in new onset pediatric type 1 and type 2 diabetes: differences and overlaps

Nieto T, Castillo B, Nieto J, Redondo MJ

Purpose: Type 1 diabetes (T1D) is the most common type of diabetes in children, but the frequency of type 2 diabetes (T2D) is increasing rapidly. Classification of diabetes is based...
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Diagnostic Value of Anti-Nuclear Antibodies: Results From Korean University-Affiliated Hospitals

Kang SH, Seo YI, Lee MH, Kim HA

Background: Unnecessary and inappropriate laboratory testing accounts for a significant portion of waste in health care utilization. The aim of this study was to examine the diagnostic value of the...
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Blood-retina barrier dysfunction in experimental autoimmune uveitis: the pathogenesis and therapeutic targets

Kim J, Chun J, Ahn M, Jung K, Moon C, Shin T

Experimental autoimmune uveitis (EAU), an animal model of human uveitis, is characterized by infiltration of autoimmune T cells in the uvea as well as in the retina of susceptible animals....
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CAR T Cell Immunotherapy Beyond Haematological Malignancy

Hupperetz C, Lah S, Kim H, Kim CH

Chimeric antigen receptor (CAR) T cells, which express a synthetic receptor engineered to target specific antigens, have demonstrated remarkable potential to treat haematological malignancies. However, their transition beyond haematological malignancy...
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Cytokines and Inflammation in Meniere Disease

Frejo L, Lopez-Escamez JA

Meniere disease (MD) is a rare set of conditions associated with the accumulation of endolymph in the cochlear duct and the vestibular labyrinth with a decrease of endocochlear potential. It...
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Autoimmune Hemolytic Anemia Combined with Sepsis After Abdominal Trauma Surgery

Moon GS, Choi YU, Shim H, Jang JY

Intra-abdominal infection is a common, serious complication in patients undergoing emergency abdominal surgery following blunt abdominal trauma. Infectious conditions increase the incidence of autoimmune hemolytic anemia (AIHA), but reports of...
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Toll-like Receptor 2 in Autoimmune Inflammation

Marks KE, Cho K, Stickling C, Reynolds JM

TLR signaling is critical for broad scale immune recognition of pathogens and/or danger molecules. TLRs are particularly important for the activation and the maturation of cells comprising the innate immune...
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Updates in postural tachycardia syndrome

Moon J

Postural tachycardia syndrome (POTS) is the most common form of orthostatic intolerance in young people. However, it is still considered an underrecognized disorder and so deserves more attention from clinicians....
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Paraneoplastic Encephalitis Associated with Locally Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

Shay RC, Diamond JR, Kagihara JA, Sams SB

Paraneoplastic neurologic diseases (PND) are rare but can occur in patients with common malignancies including breast cancer. In patients with hormone receptor (HR)-negative human epidermal growth factor receptor 2 (HER2)-positive...
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Anti-Sm Antibody, Damage Index, and Corticosteroid Use Are Associated with Cardiac Involvement in Systemic Lupus Erythematosus: Data from a Prospective Registry Study

Choe JY, Lee SS, Kwak SG, Kim SK

Background: Disease-specific factors that predispose patients to diverse cardiac diseases in systemic lupus erythematosus (SLE) have been established. The aim of this study was to identify risk factors for cardiac...
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Increased Circulating CXCL10 in Non-Segmental Vitiligo Concomitant with Autoimmune Thyroid Disease and Alopecia Areata

Zhang L, Xu X, Chen S, Kang Y, Wang X, Zhang C, Xiang L

BACKGROUND: Vitiligo is a common acquired pigmentary disease caused by destruction of epidermal melanocytes in underlying autoimmune response. Few studies have been focused on the role of chemokines in non-segmental...
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Progression of Multifaceted Immune Cells in Atherosclerotic Development

Park S, Lee IK

Atherosclerosis is a major cause of morbidity and mortality due to cardiovascular diseases, such as coronary artery disease, stroke, and peripheral vascular disease, that are associated with thrombosis-induced organ infarction....
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Sputum Autoantibodies Are More Relevant in Autoimmune Responses in Asthma than Are Serum Autoantibodies

Qin R, Long F, Xiao X, Xiao J, Zheng Z, Feng M, Huang R, Peng T, Li J

PURPOSE: The data on the differences between sputum autoantibodies (Sp-Abs) and serum autoantibodies (Se-Abs) in reflection of autoimmune responses to lungs is still lacking. METHODS: Ten types of Abs were investigated...
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Aged Sanroque Mice Spontaneously Develop Sjögren's Syndrome-like Disease

Choi SS, Jang E, Oh YK, Jang K, Cho ML, Park SH, Youn J

Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disorder that affects mainly salivary and lacrimal glands, but its cause remains largely unknown. Clinical data indicating that SS occurs in a...
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Potential Implications of Long Noncoding RNAs in Autoimmune Diseases

Hur K, Kim SH, Kim JM

Long noncoding RNAs (lncRNAs) are non-protein coding RNAs of more than 200 nucleotides in length. Despite the term “noncoding”, lncRNAs have been reported to be involved in gene expression. Accumulating...
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