Psychiatry Investig.
2018 Nov;15(11):1064-1070. 10.30773/pi.2018.10.10.1.
Association between Thioridazine Use and Cancer Risk in Adult Patients with Schizophrenia-A Population-Based Study
- Affiliations
-
- 1Department of Psychiatry, Changhua Christian Hospital, Changhua, Taiwan. changmichael@hotmail.com
- 2School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
- 3Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan.
- 4Department of Health Services Administration, China Medical University, Taichung, Taiwan.
- 5Department of Psychiatry, LuKang Christian Hospital, Lukang, Taiwan.
- 6Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
- 7Department of Health Policy and Management, Chung Shan Medical University, Taichung, Taiwan.
- 8Department of Psychiatry, Tungs’ Taichung MetroHarbor Hospital, Taichung, Taiwan.
- KMID: 2427574
- DOI: http://doi.org/10.30773/pi.2018.10.10.1
Abstract
OBJECTIVE
Several cell line studies have demonstrated thioridazine's anticancer, multidrug resistance-reversing and apoptosis-inducing properties in various tumors. We conducted this nationwide population-based study to investigate the association between thioridazine use and cancer risk among adult patients with schizophrenia.
METHODS
Based on the Psychiatric Inpatient Medical Claim of the National Health Insurance Research Database of Taiwan, a total of 185,689 insured psychiatric patients during 2000 to 2005 were identified. After excluding patients with prior history of schizophrenia, only 42,273 newly diagnosed patients were included. Among them, 1,631 patients ever receiving thioridazine for more than 30 days within 6 months were selected and paired with 6,256 randomly selected non-thioridazine controls. These patients were traced till 2012/12/31 to see if they have any malignancy.
RESULTS
The incidence rates of hypertension and cerebrovascular disease were higher among cases than among matched controls. The incidence of hyperlipidemia, coronary artery disease and chronic pulmonary disease did not differ between the two groups. By using Cox proportional hazard model for cancer incidence, the crude hazard ratio was significantly higher in age, hypertension, hyperlipidemia, cerebrovascular disease, coronary artery disease and chronic pulmornary disease. However, after adjusting for other covariates, only age and hypertension remained significant. Thioridazine use in adult patients with schizophrenia had no significant association with cancer.
CONCLUSION
Despite our finding that thioridazine use had no prevention in cancer in adult patients with schizophrenia. Based on the biological activity, thioridazine is a potential anticancer drug and further investigation in human with cancer is warranted.
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