Ann Rehabil Med.  2018 Aug;42(4):630-633. 10.5535/arm.2018.42.4.630.

The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report

• Shin J
• Park G
• Lee J
• Bae H

• KMID: 2420058
• DOI: http://doi.org/10.5535/arm.2018.42.4.630

Abstract

Polydeoxyribonucleotide (PDRN) is safe and effective in wound healing, cellular growth, synthesis of extracellular matrix protein, and inflammation reduction via activation of adenosine A2 receptors. We report a 28-year-old male patient treated with PDRN injections for chronic non-healing wound refractory to negative pressure wound therapy, skin graft, or growth factors. Three injections of PDRN were administered at the wound site into the anterior and medial sides of the left stump on the 1st, 4th, and 9th days of hospitalization. The PDRN ameliorated wound healing by enhancing cell growth, tissue repair, and angiogenesis. PDRN application represents a potential treatment for non-healing wounds obviating the need for additional therapies, and hospitalization, as well as improve patient's activities of daily living.

Keyword

Amputees; Wound healing; Polydeoxyribonucleotides

MeSH Terms

Activities of Daily Living
Adult
Amputees*
Extracellular Matrix
Hospitalization
Humans
Inflammation
Intercellular Signaling Peptides and Proteins
Male
Negative-Pressure Wound Therapy
Polydeoxyribonucleotides
Receptors, Adenosine A2
Skin
Transplants
Wound Healing
Wounds and Injuries*
Intercellular Signaling Peptides and Proteins
Polydeoxyribonucleotides
Receptors, Adenosine A2

Figure

• 

  Fig. 1. Two open wounds existed on the left lower extremity during the first visit (A). Since the first polydeoxyribonucleotide (PDRN) injection on the wound area, wound closure occurred gradually. (B) After the second PDRN injection. (C) After the third PDRN injection. After 3 PDRN injections, almost full epithelialization occurred as shown. POD, postoperative date; HD, hospital day.

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