- Dietary nobiletin suppresses TGF-β1-Src-caveolin-1 dependent signaling involved with high glucose-induced renal mesangial matrix accumulation
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Kim DY, Kang YH, Kang MK
- KMID: 2471118
- J Nutr Health.
- 2020 Feb;53(1):1-12.
- doi: 10.4163/jnh.2020.53.1.1
PURPOSE: Diabetic nephropathy is one of the most important diabetic complications prompted by chronic hyperglycemia, characterized by glomerulosclerosis, tubular fibrosis, and it eventually causes kidney failure. Nobiletin is a polymethoxyflavone... -
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- Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
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Kim MJ, Kim NY, Jung YA, Lee S, Jung GS, Kim JG, Lee IK, Lee S, Choi YK, Park KG
- KMID: 2470966
- Diabetes Metab J.
- 2020 Feb;44(1):186-192.
- doi: 10.4093/dmj.2018.0271
Renal fibrosis is considered to be the final common outcome of chronic kidney disease. Dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated protective effects against diabetic kidney disease. However, the anti-fibrotic effect... -
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- Matrix Metallopeptidase 3 Polymorphisms: Emerging genetic Markers in Human Breast Cancer Metastasis
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Suhaimi SA, Chan SC, Rosli R
- KMID: 2470877
- J Breast Cancer.
- 2020 Feb;23(1):1-9.
- doi: 10.4048/jbc.2020.23.e17
Matrix metallopeptidase 3 or MMP3, is a zinc-dependent proteolytic enzyme that is involved in various physiological processes via modification of the extracellular matrix. In particular, its over-expression has been associated... -
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- Diffuse Systemic Sclerosis in a Patient with Primary Biliary Cirrhosis and Autoimmune Hepatitis Overlap Syndrome: A Case Report
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Han HS, Ahn GR, Kim HJ, Park KY, Li K, Seo SJ
- KMID: 2467204
- Ann Dermatol.
- 2020 Feb;32(1):69-73.
- doi: 10.5021/ad.2020.32.1.69
Systemic sclerosis (SSc) is a chronic systemic disease of unknown etiology characterized by vasculopathy, excessive accumulation of extracellular matrix, and fibrosis of the skin and other internal organs. Although its... -
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- Follistatin Mitigates Myofibroblast Differentiation and Collagen Synthesis of Fibroblasts from Scar Tissue around Injured Flexor Tendons
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Kang YM, Lee SK, Chun YM, Choi YR, Moon SH, Lee HM, Kang HJ
- KMID: 2466340
- Yonsei Med J.
- 2020 Jan;61(1):85-93.
- doi: 10.3349/ymj.2020.61.1.85
PURPOSE: The aim of this study was to investigate the effect of FST gene on the inhibition of fibrosis in fibroblastic cells from scar tissue around repaired zone II flexor... -
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- Skeletal mineralization: mechanisms and diseases
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Michigami
- KMID: 2468721
- Ann Pediatr Endocrinol Metab.
- 2019 Dec;24(4):213-219.
- doi: 10.6065/apem.2019.24.4.213
Skeletal mineralization is initiated in matrix vesicles (MVs), the small extracellular vesicles derived from osteoblasts and chondrocytes. Calcium and inorganic phosphate (Pi) taken up by MVs form hydroxyapatite crystals, which... -
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- Maintenance of hPSCs under Xeno-Free and Chemically Defined Culture Conditions
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Lim JJ, Kim HJ, Rhie BH, Lee MR, Choi MJ, Hong SH, Kim KS
- KMID: 2465889
- Int J Stem Cells.
- 2019 Nov;12(3):484-496.
- doi: 10.15283/ijsc19090
Previously, the majority of human embryonic stem cells and human induced pluripotent stem cells have been derived on feeder layers and chemically undefined medium. Those media components related to feeder... -
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- Frozen-thawed gelatin-induced osteogenic cell sheets of canine adipose-derived mesenchymal stromal cells improved fracture healing in canine model
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Yoon Y, Jung T, Afan Shahid M, Khan IU, Kim WH, Kweon OK
- KMID: 2464079
- J Vet Sci.
- 2019 Nov;20(6):e63.
- doi: 10.4142/jvs.2019.20.e63
We assessed the efficacy of frozen-thawed gelatin-induced osteogenic cell sheet (FT-GCS) compared to that of fresh gelatin-induced osteogenic cell sheet (F-GCS) with adipose-derived mesenchymal stromal cells (Ad-MSCs) used as the... -
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- Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes
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Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY
- KMID: 2462880
- Biomol Ther.
- 2019 Nov;27(6):530-539.
- doi: 10.4062/biomolther.2019.151
Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and... -
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- LncRNA MALAT1/MiR-145 Adjusts IL-1β-Induced Chondrocytes Viability and Cartilage Matrix Degradation by Regulating ADAMTS5 in Human Osteoarthritis
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Liu C, Ren S, Zhao S, Wang Y
- KMID: 2460226
- Yonsei Med J.
- 2019 Nov;60(11):1081-1092.
- doi: 10.3349/ymj.2019.60.11.1081
PURPOSE: Accumulating evidence suggests that microRNA-145 (miR-145) plays an important role in osteoarthritis (OA), which is a chronic progressive joint disease. Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)... -
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- Three-Dimensional Spheroid Formation of Cryopreserved Human Dental Follicle-Derived Stem Cells Enhances Pluripotency and Osteogenic Induction Properties
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Kim HJ, Sung IY, Cho YC, Kang MS, Rho GJ, Byun JH, Park WU, Son MG, Park BW, Lee HJ, Kang YH
- KMID: 2464071
- Tissue Eng Regen Med.
- 2019 Oct;16(5):513-523.
- doi: 10.1007/s13770-019-00203-0
BACKGROUND: Enhancement and maintenance of the stemness of mesenchymal stem cells (MSCs) is one of the most important factors contributing to the successful in vivo therapeutic application of these cells.... -
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- Comparison of Transforming Growth Factor-Beta1 and Lovastatin on Differentiating Mesenchymal Stem Cells toward Nucleus Pulposus-like Phenotype: An In Vitro Cell Culture Study
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Yang SH, Yang KC, Chen CW, Huang TC, Sun YH, Hu MH
- KMID: 2461998
- Asian Spine J.
- 2019 Oct;13(5):705-712.
- doi: 10.31616/asj.2018.0257
STUDY DESIGN: In Vitro cell culture study. PURPOSE: This study aims to investigate the impact of transforming growth factor-beta1 (TGF-β1) and lovastatin on differentiating human mesenchymal stem cells (MSCs) toward nucleus... -
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- The Clinical Uses of Collagen-Based Matrices in the Treatment of Chronic Wounds
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Yang HJ, Kang SY
- KMID: 2465852
- J Wound Manag Res.
- 2019 Sep;15(2):103-108.
- doi: 10.22467/jwmr.2019.00640
Chronic wounds are defined as wounds that fail to heal completely at the pace and order observed in normal phases of wound healing. Whereas acute wounds proceed through the normal... -
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- The Genomic Landscape and Its Clinical Implications in Hepatocellular Carcinoma
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Yim SY, Lee JS
- KMID: 2463610
- J Liver Cancer.
- 2019 Sep;19(2):97-107.
- doi: 10.17998/jlc.19.2.97
The pathogenesis of hepatocellular carcinoma (HCC) is a complex process. During the last decade, advances in genomic technologies enabled delineation of the genomic landscape of HCC, resulting in the identification... -
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- In Vitro and In Vivo Study on the Effect of Lysosome-associated Protein Transmembrane 4 Beta on the Progression of Breast Cancer
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Tao D, Liang J, Pan Y, Zhou Y, Feng Y, Zhang L, Xu J, Wang H, He P, Yao J, Zhao Y, Ning Q, Wang W, Jiang W, Zheng J, Wu X
- KMID: 2458859
- J Breast Cancer.
- 2019 Sep;22(3):375-386.
- doi: 10.4048/jbc.2019.22.e43
PURPOSE: Although the effect of lysosome-associated protein transmembrane 4 beta (LAPTM4B) on the proliferation, migration, and invasion of breast cancer (BC) cells has already been studied, its specific role in... -
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- Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model
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Yun IS, Kang E, Ahn HM, Kim YO, Rah DK, Roh TS, Lee WJ, Yun CO
- KMID: 2457481
- Yonsei Med J.
- 2019 Sep;60(9):854-863.
- doi: 10.3349/ymj.2019.60.9.854
PURPOSE: Relaxin (RLX) is a transforming growth factor-β1 (TGF-β1) antagonist that is believed to function as a potent collagen re-arranger and a major suppressor of extracellular matrix components. Adenoviruses (Ads)... -
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- Preparation and Characterization of Human Adipose Tissue-Derived Extracellular Matrix, Growth Factors, and Stem Cells: A Concise Review
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Chun SY, Lim JO, Lee EH, Han MH, Ha YS, Lee JN, Kim BS, Park MJ, Yeo M, Jung B, Kwon TG
- KMID: 2455047
- Tissue Eng Regen Med.
- 2019 Aug;16(4):385-393.
- doi: 10.1007/s13770-019-00199-7
BACKGROUND: Human adipose tissue is routinely discarded as medical waste. However, this tissue may have valuable clinical applications since methods have been devised to effectively isolate adipose-derived extracellular matrix (ECM),... -
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- Characterization and Differentiation of Circulating Blood Mesenchymal Stem Cells and the Role of Phosphatidylinositol 3-Kinase in Modulating the Adhesion
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Park YK, Heo SJ, Koak JY, Park GS, Cho TJ, Kim SK, Cho J
- KMID: 2465897
- Int J Stem Cells.
- 2019 Jul;12(2):265-278.
- doi: 10.15283/ijsc18136
Bone marrow mesenchymal stem cells (BM MSCs) can differentiate into multi-lineage tissues. However, obtaining BM MSCs by aspiration is difficult and can be painful; therefore peripheral blood (PB) MSCs might... -
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- Urinary transglutaminase 2 as a potent biomarker to predict interstitial fibrosis and tubular atrophy of kidney allograft during early posttransplant period in deceased donor kidney transplantation
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Kim JY, Wee YM, Choi MY, Jung HR, Choi JY, Kwon HW, Jung JH, Cho YM, Go H, Han M, Kim YH, Han DJ, Shin S
- KMID: 2450987
- Ann Surg Treat Res.
- 2019 Jul;97(1):27-35.
- doi: 10.4174/astr.2019.97.1.27
PURPOSE: Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested whether quantification of urinary TG2 may represent a noninvasive method... -
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- Effect of Manuka Honey on Transforming Growth Factor Beta-1-Induced Extracelluar Matrix Production in Nasal Polyp Derived Fibroblasts
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Kil BK, Kim BM, Kang BJ, Ye MK, Shin SH
- KMID: 2451614
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2019 Jun;62(6):336-342.
- doi: 10.3342/kjorl-hns.2018.00682
BACKGROUND AND OBJECTIVES: Manuka honey has anti-microbial, anti-inflammatory, and anti-proliferative action with a high concentration of methylglyoxal compound. It is also effective in killing Staphylococcus aureus biofilm and effective for... -
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