Korean J Urol Oncol.  2017 Dec;15(3):152-157. 10.22465/kjuo.2017.15.3.152.

Elevated Ki-67 (MIB-1) Expression as an Independent Predictor for Poor Prognosis After Radical Cystectomy for Bladder Cancer

• Lee H
• Lee DH
• Chung Y
• Nguyen NH
• Oh JJ
• Lee S
• Lee SE
• Hong SK
• Byun SS

• KMID: 2402597
• DOI: http://doi.org/10.22465/kjuo.2017.15.3.152

Abstract

PURPOSE
We tried to investigate the clinical impact of Ki-67 (MIB-1) expression on the oncological and survival outcomes in patients with bladder cancer (BCa) after the radical cystectomy.
MATERIALS AND METHODS
We retrospectively analyzed the data of 230 patients who were treated by radical cystectomy for BCa. Multivariate Cox-proportional hazards models and logistic regression tests were performed to evaluate the prognostic value of each variable.
RESULTS
The patients with positive Ki-67 expression showed significant worse clinical characteristics and pathologic outcomes than negative Ki-67 group. Furthermore, the patients with Ki-67 expression showed significant worse recurrence (p=0.018) and cancer-specific mortality free survival (p=0.019) than negative Ki-67 group. The overall survival was also revealed to be inferior in Ki-67 positive group than Ki-67 negative group but the statistical significance was marginal (p=0.062). Subsequent multivariate Cox analyses showed that Ki-67 was independent predictor for disease recurrence after surgery (hazard ratio, 3.142; 95% CI, 1.287-7.671; p=0.012).
CONCLUSIONS
In our study, high Ki-67 expression was significantly related with worse clinical outcomes after radical cystectomy in the patients with BCa. Further prospective and basic researches are needed to validate the true prognostic value of Ki-67.

Keyword

Bladder cancer; Cystectomy; Ki-67; Survival; Recurrence

MeSH Terms

Cystectomy*
Humans
Logistic Models
Mortality
Prognosis*
Proportional Hazards Models
Prospective Studies
Recurrence
Retrospective Studies
Urinary Bladder Neoplasms*
Urinary Bladder*