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Clinical Grading System, Surgical Outcomes and Prognostic Analysis of Cranial Base Chordomas

Wang B, Tian F, Tong X

Objective : Cranial base chordomas are rare, but their treatment is challenging. Tumor recurrence is still common despite improvements in microsurgical techniques and postoperative radiotherapy. We retrospectively analyzed the course...
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Fatty acid synthetase expression in triple-negative breast cancer

Park JH, Han HS, Lim SD, Kim WY, Park KS, Yoo YB, Lee SE, Kim WS

Background: Triple-negative breast cancer (TNBC) has a relatively poor prognosis. Research has identified potential metabolic targets, including fatty acid metabolism, in TNBC. The absence of effective target therapies for TNBC...
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Influence of Androgen Receptor Antagonist MDV3100 Therapy on Rats With Benign Prostatic Hyperplasia

Yang M, Xu Z, Zhuang Z

Purpose: To probe the effect and mechanism of androgen receptor antagonist MDV3100 on benign prostatic hyperplasia (BPH) of rats Methods: BPH rat model was induced by testosterone propionate. Then antagomir-miR-21-3p or...
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Histopathological Analysis of Esophageal Mucosa in Patients with Achalasia

Lee BE, Kim GH, Shin N, Park DY, Song GA

Background/Aims: Achalasia is an esophageal motor disorder that leads to functional esophageal obstruction. Food stasis and bacterial fermentation can predispose an individual to esophageal mucosal inflammation, causing multifocal dysplasia and...
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Analysis of Mutant Isocitrate Dehydrogenase 1 Immunoexpression, Ki-67 and Programmed Death Ligand 1 in Diffuse Astrocytic Tumours : Study of Single Center in Bandung, Indonesia

Bolly HMB, Faried A, Hermanto Y, Lubis BP, Tjahjono FP, Hernowo BS, Arifin MZ

Objective : Diffuse astrocytic tumour (DAT) is a diffuse infiltrative astrocytoma tumour accompanied by molecular parameters such as the presence or absence of isocitrate dehydrogenase (IDH) gene mutations. Ki-67 is...
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Clinical outcome and predictive factors for docetaxel and epirubicin neoadjuvant chemotherapy of locally advanced breast cancer

Won HS, Kim YS, Kim JS, Chang ED, Na SJ, Whang IY, Lee DS

Background/Aims: We evaluated the efficacy of docetaxel and epirubicin as neoadjuvant chemotherapy in locally advanced breast cancer and assessed the predictive factors for response to neoadjuvant chemotherapy and prognostic factors...
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Molecular and Clinicopathological Features of Gastrointestinal Stromal Tumors in Vietnamese Patients

Ngo QD, Pham QT, Phan DA, Hoang AV, Hua TN, Nguyen ST

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. Management of GIST patients is currently based on clinicopathological features and associated genetic changes. However,...
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The Use of CD44 Variant 9 and Ki-67 Combination Can Predicts Prognosis Better Than Their Single Use in Early Gastric Cancer

Go SI, Ko GH, Lee WS, Lee JH, Jeong SH, Lee YJ, Hong SC, Ha WS

PURPOSE: We previously demonstrated that CD44v9 and Ki-67 played an important role in predicting poor prognosis of early gastric cancer (EGC). However, little is known about combined use of both...
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Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects

Hyriavenko N, Lyndin M, Sikora K, Piddubnyi , Karpenko L, Kravtsova , Hyriavenko D, Diachenko , Sikora V, Romaniuk A

BACKGROUND: Although primary cancer of the fallopian tubes is a relatively rare type of tumor in female reproductive organs, its mortality is quite high. It is important to identify molecular...
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Potential Role for a Panel of Immunohistochemical Markers in the Management of Endometrial Carcinoma

Salama A, Arafa M, ElZahaf E, Shebl AM, Awad AA, Ashamallah SA, Hemida R, Gamal A, Foda AA, Zalata K, Abdel-Hady ESM

BACKGROUND: In order to improve the efficacy of endometrial carcinoma (EC) treatment, identifying prognostic factors for high risk patients is a high research priority. This study aimed to assess the...
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Ki-67 labeling index as a prognostic marker in advanced stomach cancer

Seo SH, Kim KH, Oh SH, Choi Y, Ahn KJ, Lee JY, Lee SM, Park J, Kim WG

PURPOSE: Proliferation marker Ki-67 is widely used in cancer prognosis prediction. We tried to investigate the role of Ki-67 as a prognostic factor in stomach cancer after surgery in this...
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Inhibitory effects of Pycnogenol®, a pine bark extract, in a rat model of testosterone propionate-induced benign prostatic hyperplasia

Ko JW, Park SW, Shin NR, Kim WI, Kim JC, Shin IS, Shin DH

Benign prostate hyperplasia (BPH) is a male reproductive disease that has gained increasing importance in recent years. The present study investigated whether Pycnogenol® (PYC), a standardized French maritime pine bark...
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Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma

Azizan N, Hayati F, Tizen NM, Farouk WI, Masir N

PURPOSE: To evaluate the expression of estrogen receptor (ER)-beta and Ki67 in prostate cancer and study their relationship. MATERIALS AND METHODS: We analyzed 101 cases of prostate adenocarcinoma diagnosed from January...
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Expression of p63 and its association with cell proliferation at different stages of murine hair follicle cycle

Lee BW, Oh JW, Seo M, Hwang JS, Yoon B

In the present study, we investigated the expression patterns of p63, a member of the p53 gene family, in hair follicle cells at different stages of the hair cycle and...
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Elevated Ki-67 (MIB-1) Expression as an Independent Predictor for Poor Prognosis After Radical Cystectomy for Bladder Cancer

Lee H, Lee DH, Chung Y, Nguyen NH, Oh JJ, Lee S, Lee SE, Hong SK, Byun SS

PURPOSE: We tried to investigate the clinical impact of Ki-67 (MIB-1) expression on the oncological and survival outcomes in patients with bladder cancer (BCa) after the radical cystectomy. MATERIALS AND METHODS:...
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Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation With Its Destructive Capacity

Hamed MA, Nakata S, Shiogama K, Suzuki K, Sayed RH, Nishimura , Iwata N, Sakurai K, Badawy BS, Inada K, Tsuge H, Tsutsumi Y

OBJECTIVES: Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is...
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High Histologic Grade and High Ki-67 Expression Predict Phenotypic Alterations in Node Metastasis in Primary Breast Cancers

Mandó P, Rizzo M, de la Puente CP, Maino M, Ponce C, Pombo MT, Amat M, Costanzo M, Nervo A, Nadal J, Fabiano V, Loza J, Loza CM, Colo F, Reinaldo C

PURPOSE: Several studies have shown that estrogen receptor (ER) and progesterone receptor (PR) expression and human epidermal growth factor receptor 2 (HER2) expression may vary during tumoral progression. We aimed...
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Myxoid and Sarcomatoid Variants of Adrenocortical Carcinoma: Analysis of Rare Variants in Single Tertiary Care Center

Sung TY, Choi YM, Kim WG, Lee YM, Kim TY, Shong YK, Kim WB, Song DE

The aim of this study is to describe rare variants of adrenocortical carcinoma (ACC) and to compare the prognosis with that of conventional ACC. We retrospectively reviewed 8 cases of...
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A Case of a Rapidly Progressive Small Bowel Lymphoma with High Ki-67 Expression

Yoo J, Kang HJ, Kim H, Han S, Oh SH, Jung SH, Oh JH, Jeon EJ

Primary intestinal lymphoma is a rare disease. It accounts for approximately 1~4% of gastrointestinal malignancy. Extranodal lymphoma of the intestine mainly arises from B cells. Diffuse large B-cell lymphoma is...
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Diagnostic Significance of Cellular Neuroglial Tissue in Ovarian Immature Teratoma

Chai Y, Woo CG, Kim JY, Kim CJ, Khang SK, Kim J, Park IA, Kim EN, Kim KR

BACKGROUND: Immature teratoma (IT) is a tumor containing immature neuroectodermal tissue, primarily in the form of neuroepithelial tubules. However, the diagnosis of tumors containing only cellular neuroglial tissue (CNT) without...
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