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Malignant melanoma of the gallbladder: A case report and literature review

Jeon HJ, Kwon HJ, Kim SG, Hwang YJ

Metastatic melanoma of the gallbladder is extremely rare. It has a poor prognosis. Its optimal treatment remains unclear. Surgical resection is generally considered the mainstay of treatment. However, there are...
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Increased Risk of Recurrence of Non-Muscle Invasive Bladder Cancer Associated With Psychological Distress: A Prospective Cohort Study

Qian Z, Ding W, Zhou Q, Ge S, Sun C, Xu K

Objective The primary aim was to evaluate the influence of depressive and anxiety symptoms on the 1-year recurrence rate of non-muscle invasive bladder cancer (NMIBC) patients. The secondary aim was...
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Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion

Lee TH, Heo JH, Jeong JY, Lee GH, Park DS, Kim TH

Purpose: Eph receptors are differentially expressed in numerous malignant tumors. This study intended to analyze the roles of EphB receptors (EphB2, B3, and B4) in urinary bladder cancer. Materials and Methods:...
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Gender Difference in Gallbladder Cancer: Focusing on the Clinical Characteristics, Treatment, and Prognosis of Korean Patients

Kim EJ

Gallbladder cancer (GBC) is a relatively uncommon malignancy of the gastrointestinal tract, but it has a poor prognosis. Most cases of GBC are initially diagnosed in advanced stage and the...
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Laparoscopic Radical Cystectomy With Intracorporeal Orthotopic Neobladder Reconstruction: An Initial Experience of Modified Studer Reconstruction Techniques

Kim JH

This study aimed to describe the initial experience of laparoscopic radical cystectomy (LRC) with total intracorporeal urinary diversion (ICUD). The procedure was performed in a male patient using a 5-port...
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Clinical Implications of Urinary Microbiome in Bladder Cancer

Shim JH, Gook JH, Chang IH, Sohn JM, Seong SW, Chi BH

Microbiomes are known to have a beneficial effect on human health by promoting the effective removal of improperly functioning immune cells and protecting the host from pathogen infection. On the...
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Recurrence of Subepithelial Non-Muscle Invasive Bladder Cancer Following Transurethral Resection: A Case Report

Kim N, Moon SK, You Mw, Lim JW

Transurethral resection (TUR) is the gold standard treatment of non-muscle invasive bladder cancers. Recurrence occurs in approximately half of the patients with bladder cancer after initial TUR. Most recurrent bladder...
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Association of immunohistochemical markers of tumor subtype with response to neoadjuvant chemotherapy and survival in patients with muscle-invasive bladder cancer

Razzaghdoust A, Ghajari M, Basiri A, Torbati PM, Jafari A, Fattahi MR, Salahi M, Mofid B

Purpose: A readily accessible biomarker to identify which patients with bladder cancer are more likely to respond to neoadjuvant chemotherapy (NAC) could help clinicians avoid unnecessary chemotherapy and prevent its...
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Emerging agents for the treatment of metastatic urothelial cancer

Kwon WA, Seo HK

Over the past few decades, platinum-based combination chemotherapy (PBCC) has been the preferred initial therapy for metastatic urothelial cancer (mUC). However, despite a response rate of approximately 50%, a small...
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Sulforaphane Inhibits ICAM-1 Expression and Monocyte Adhesion in Human Bladder Cancer T24 Cells

Ahn KY, Khoi PN, Cho YS, Li S, Sah DK, Xia Y, Jung YD

Intracellular adhesion molecule-1 (ICAM-1) belongs to the immunoglobulin-like superfamily of adhesion molecules that mediate cell adhesion to other cells, and ICAM-1 is involved in cancer progression and recurrence. Since the...
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Centromere protein U enhances the progression of bladder cancer by promoting mitochondrial ribosomal protein s28 expression

Liu BB, Ma T, Sun W, Gao WY, Liu JM, Li LQ, Li WY, Wang S, Guo YY

Bladder cancer is one of the most common types of cancer. Most gene mutations related to bladder cancer are dominantly acquired gene mutations and are not inherited. Previous comparative transcriptome...
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KAT8/MOF-Mediated Anti-Cancer Mechanism of Gemcitabine in Human Bladder Cancer Cells

Zhu H, Wang Y, Wei T, Zhao X, Li F, Li Y, Wang F, Cai Y, Jin J

Histone acetylation is a well-characterized epigenetic modification controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Imbalanced histone acetylation has been observed in many primary cancers. Therefore, efforts have been...
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Hilar portal vein wedge resection and patch venoplasty in patients undergoing bile duct resection for hepatobiliary malignancy: A report of two cases

Kim SM, Hwang S

Margin-free resection is one of the most important factors for favorable prognosis in patients undergoing resection for hepatobiliary malignancies. Herein, we present two cases of hepatobiliary malignancies in patients who...
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The Effects of Recombinant Bacillus Calmette-Guérin Resistant to Antimicrobial Peptides on Orthotopic Bladder Cancer Mouse Model

Hong SJ, Hwang GY, Kang SJ, Choi SY, Chi BH, Chang IH

Purpose: Although Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is the most widely used bladder cancer immunotherapy, innate immune responses involving antimicrobial peptides (AMPs) cause BCG failure. Here, we developed genetically modified...
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T1-Staging for Urinary Bladder Cancer with the Stalk and Inchworm Signs with 3.0 Tesla MRI

Kim Dh, Kang BC, Chung J

Purpose: To evaluate the diagnostic utility of the stalk and the inchworm sign on preoperative MRI for detecting superficial bladder cancers, and to compare the diagnostic performance between the stalk...
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Rates and Risk Factors of Bacteriuria in Patients with Bladder Cancer Who Underwent Treatment with Bacillus Calmette-Guérin

Eun SJ, Kim MS, Jung SI, Choi HJ, Chung HS, Hwang EC, Kwon DD

Purpose: This study evaluated the rate and predictors of bacteriuria in patients who underwent transurethral resection of bladder tumor (TURBT) and Bacillus Calmette-Guérin (BCG) treatment. Materials and Methods: We prospectively evaluated...
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Synergistic Antitumor Effects of Combined Treatment with HSP90 Inhibitor and PI3K/mTOR Dual Inhibitor in Cisplatin-Resistant Human Bladder Cancer Cells

Kim HJ, Gong MK, Yoon CY, Kang J, Yun M, Cho NH, Rha SY, Choi YD

Purpose: The current study aimed to investigate the synergistic antitumor effect of combined treatment with 17-DMAG (HSP90 inhibitor) and NVP-BEZ235 (PI3K/mTOR dual inhibitor) on cisplatin-resistant human bladder cancer cells. Materials and...
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Obesity and Pancreatobiliary Disease

Lee H, Koh DH

Obesity has become a major medical and public health problem worldwide. Recent studies have shown that obesity is a chronic disease that is associated with many diseases, such as gallstone...
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Detection of Incidental Prostate Cancer or Urothelial Carcinoma Extension in Urinary Bladder Cancer Patients by Using Multiparametric MRI: A Retrospective Study Using Prostate Imaging Reporting and Data System Version 2.0

Yoon SE, Kang BC, Cho HH, Park S

Purpose The study aimed to investigate the role of Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) in predicting incidental prostate cancer (PCa) or urothelial carcinoma (UCa) extension...
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Prevalence and Clinicopathological Significance of METOverexpression and Gene Amplification in Patients withGallbladder Carcinoma

Kim Y, Bang SS, Jee S, Park S, Shin SJ, Jang K

Purpose Mesenchymal epithelial transition (MET) is a proto-oncogene that encodes a heterodimeric transmembrane receptor tyrosine kinase for the hepatocyte growth factor. Aberrant MET signaling has been described in several solid tumors—especially non-small cell...
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