Ann Lab Med.  2018 Jan;38(1):59-62. 10.3343/alm.2018.38.1.59.

Chinese Pediatric Reference Intervals for Serum Cortisol on IMMULITE 2000

Affiliations
  • 1Unit of Laboratory Medicine, Second Hospital Affiliated to Wenzhou Medical University, Wenzhou, China.
  • 2College of Medicine, Zhejiang University, Hangzhou, China.
  • 3College of Life and Environmental Science, Wenzhou University, Wenzhou, China. sherwood@wzu.edu.cn

Abstract

Clinical interpretation of the test results for cortisol based on continuous reference intervals with appropriate partitions improves pediatric diagnosis; however, these values are available only for Caucasians. To develop the pediatric reference intervals for Chinese population, we examined the serum cortisol levels in 1,143 healthy Chinese children aged 4-18 years (566 boys and 577 girls), using an IMMULITE 2000 Immunoassay System (Siemens Healthcare GmbH). Phlebotomy was performed at 7-9 a.m. for 284 boys and 287 girls and at 1-3 p.m. for the others. They were divided into four age groups according to the Clinical and Laboratory Standards Institute guideline EP28-A3c, with the last group further stratified according to sampling time. Separate reference intervals of 49.6-323.7, 70.9-395.3, and 90.1-448.7 nmol/L were established for children aged 4-8, 9-12, and 13-15 years, respectively. Further, reference intervals of 118.2-464.7 and 71.4-446.7 nmol/L were established for morning and afternoon cortisol levels, respectively, in children aged 16-18 years. Further studies are necessary to transfer and validate these reference intervals in other analytical systems and pediatric populations, and to allow for broader applications.

Keyword

Cortisol; Reference interval; Pediatrics; Chinese

MeSH Terms

Asian Continental Ancestry Group*
Child
Delivery of Health Care
Diagnosis
Female
Humans
Hydrocortisone*
Immunoassay
Pediatrics
Phlebotomy
Hydrocortisone
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