Tissue Eng Regen Med.
2017 Jun;14(3):221-231. 10.1007/s13770-017-0055-0.
Comparison of Bio-degradation for Ridge Preservation Using Silk Fibroin-based Grafts and a Collagen Plug
- Affiliations
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- 1Department of Oral and Maxillofacial Surgery, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea.
- 2Sericultural and Apicultural Materials Division, National Academy of Agricultural Science, Wanju-gun 55365, Republic of Korea.
- 3Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Jukheon gil 7, Gangneung, Gangwondo 25457, Republic of Korea. kimsg@gwnu.ac.kr
- 4Daegu Center, Korea Basic Science Institute, Daegu 41566, Republic of Korea.
- KMID: 2395079
- DOI: http://doi.org/10.1007/s13770-017-0055-0
Abstract
- A material for ridge preservation should have dimensional stability to resist bio-degradation. This study was designed to compare bio-degradation of ridge preservation materials. Collagen plug was used as a positive control. Untreated, ethanol-treated, and 4-hexylresorcinol (4HR)-treated silk plugs were used for the experimental group. Each material underwent a scanning electron microscopic exam and a Fourier transform infrared (FT-IR) spectroscopic exam. Bio-degradation was evaluated by analyzing cylindrical bony defects in rabbit tibias. There were no prominent differences in microstructure among the silk plug groups. FT-IR exam demonstrated that the ethanol- and 4HR-treated silk plug groups had enhanced β-sheet structure. All silk plug groups exhibited significantly higher residual graft than the collagen plug group 4 weeks postoperative (p<0.05). In conclusion, silk fibroin-based ridge preservation material was less bio-degradable than a collagen plug until at least 4 weeks after grafting.
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