Maxillofac Plast Reconstr Surg.  2023;45(1):2. 10.1186/s40902-022-00368-0.

The optimal scaffold for silk sericin‑based bone graft: collagen versus gelatin

• Lee J
• Kweon H
• Oh J
• Kim S

• KMID: 2552551
• DOI: http://doi.org/10.1186/s40902-022-00368-0

Abstract

Background
Silk sericin is an active ingredient in bone grafts. However, the optimal scaffold for silk sericin has yet to be identified. Method A critical-sized bone defect model in rat calvaria was used to evaluate bone regeneration. Silk sericin from Yeonnokjam, Bombyx mori, was incorporated into gelatin (group G, n = 6) and collagen (group C, n = 6). Bone regen‑eration was evaluated using micro-computed tomography (mCT) and histology.
Results
Group C showed a larger bone volume than group G in the mCT analysis (P = 0.001). Histological analysis showed a larger area of bony defects in group G than in group C. The bone regeneration area in group C was signifi‑cantly larger than that in group G (P = 0.003).
Conclusion
Compared with gelatin, collagen shows better bone regeneration in silk sericin-based bone grafts.

Keyword

Silk sericin; Collagen; Gelatin; Scaffold; Bone graft